Determining the accumulation potential of nanoplastics in crops: An investigation of C-labelled polystyrene nanoplastic into radishes.

The capacity of crops to accumulate nanoplastics has remained relatively unexplored largely due to analytical constraints. To address this challenge, the present study employed a radiolabelling approach to demonstrate, for the first time, that polystyrene nanoplastics (C-PS NPs) accumulate and move into the tissues of radishes (Raphanus sativus). Radishes were exposed hydroponically for five days, with only their non-fleshy roots in contact with the C-PS NPs, while accumulation in the fleshy (edible) roots and shoots was subsequently measured.

High Frequency of Variants Associated with Benign and Malignant Liver Tumors in Patients with Congenital Porto-Systemic Shunts.

Introduction: Patients born with congenital porto-systemic shunts have been shown to have a high risk of benign and malignant liver tumors in otherwise healthy livers. This study aimed to evaluate the genetic landscape of liver tumors in patients with congenital porto-systemic shunts (CPSS) and correlate genotype with histological findings.

Methods: Nodules from patients with CPSS and sporadic pediatric focal nodular hyperplasia (FNH) or FNH-like nodules were evaluated histologically and sequenced for a panel of 50 genes using next-generation sequencing.

Successful AAV8 gene therapy on hepatic ex situ machine perfusion for mitochondrial neurogastrointestinal encephalomyopathy.

Ex situ normothermic machine perfusion (NMP) is rapidly emerging as a novel platform for testing therapeutics in human donor livers. Recently perfusion of explanted patient livers was achieved, raising the possibility of using these diseased organs to increase the fidelity and resolution of drug testing and development. Here, we provide proof-of-principle for the feasibility of this approach in the context of gene therapy.

Phenotypic Divergence of JAG1- and NOTCH2-Associated Alagille Syndrome & Disease-Specific NOTCH2 Variant Classification Guidelines.

Background & Aims: Alagille syndrome (ALGS) is a rare, autosomal dominant disorder with high phenotypic heterogeneity. Disease-causing variants are primarily identified in Jagged1 (JAG1), with fewer reported in NOTCH2. JAG1 variants cause disease through a mechanism of haploinsufficiency, but the mechanism for NOTCH2 variants is not completely understood, making classification of variants more challenging.

Telehealth and Online Cognitive Behavioral Therapy-Based Treatments for High-Impact Chronic Pain: A Randomized Clinical Trial.

Importance: Cognitive behavioral therapy (CBT) skills training interventions are recommended first-line nonpharmacologic treatment for chronic pain, yet they are not widely accessible.

Objective: To examine effectiveness of remote, scalable CBT-based chronic pain (CBT-CP) treatments (telehealth and self-completed online) for individuals with high-impact chronic pain, compared with usual care.

Design, Setting, And Participants: This comparative effectiveness, 3-group, phase 3 randomized clinical trial enrolled 2331 eligible patients with high-impact chronic musculoskeletal pain from 4 geographically diverse health care systems in the US from January 2021 through February 2023.

Hemostatic Benefits of an Absorbable Polysaccharide Powder in Redo Cardiac Surgery: A Comparative Study.

Background: Redo cardiac surgery outcomes, including increased transfusions and risk of reoperation, worsen with post-operative bleeding. This study aimed to directly compare the use of an absorbable polysaccharide powder to no hemostatic agent use during planned non-emergent redo cardiac surgery.

Methods: Fifty-one participants in two cohorts underwent planned non-emergent redo cardiac surgery.

Transposable elements as novel therapeutic targets for PARPi-induced synthetic lethality in PcG-mutated blood cancer.

Loss-of-function (LoF) mutations frequently found in human cancers are generally intractable by classical small molecule inhibitor approaches. Among them are mutations affecting polycomb-group (PcG) epigenetic regulators, EZH2 and ASXL1 frequently found in haematological malignancies of myeloid or lymphoid lineage, and their concurrent mutations associates with particularly poor prognosis. While there is clear need to develop novel and effective treatments for these patients, the lack of appropriate disease models and mechanistic insights have significantly hindered the progresses.

Hindsight informs foresight: revisiting millennial forecasts of impacts and status of rocky shores in 2025.

Rocky shorelines are characterised by vulnerability to both land- and sea-derived impacts. They face acute impacts such as pollution from shipping accidents, chronic pollution from point sources, run-off and catchments plus disturbances by food gathering, recreation and sediment deposition in sheltered areas. Coastal urbanisation can both impact natural shores and create impoverished artificial rocky shores.

Clinical response to azacitidine in MDS is associated with distinct DNA methylation changes in HSPCs.

Hypomethylating agents are frontline therapies for myelodysplastic neoplasms (MDS), yet clinical responses remain unpredictable. We conducted a phase 2 trial comparing injectable and oral azacitidine (AZA) administered over one or three weeks per four-week cycle, with the primary objective of investigating whether response is linked to in vivo drug incorporation or DNA hypomethylation. Our findings show that injection results in higher drug incorporation, but lower DNA demethylation per cycle, while global DNA methylation levels in mononuclear cells are comparable between responders and non-responders.

MRI Assessment of Lung Water Density in Individuals Previously Infected With COVID-19: A Cross-Sectional Study.

Background: Lung damage in post-acute COVID-19 is a common clinical finding. Lung water density (LWD) imaging using ultrashort echo time (UTE) MRI with proton-density weighting is sensitive to edema and fibrosis.

Purpose: To characterize LWD in COVID-19 survivors, compared with a healthy cohort.

Outcomes of Pediatric Facial Laceration Repair Using 5-0 Fast Absorbing Gut Sutures With and Without Overlying Adhesive Strips: A Randomized Controlled Trial.

Objectives: A randomized controlled trial was designed to compare 2 methods of repairing simple pediatric facial lacerations. We hypothesized that wounds repaired with 5-0 fast-absorbing gut sutures and overlying adhesive strips would be superior with regard to cosmetic outcome compared with 5-0 fast-absorbing gut sutures alone.

Methods: Patients 0 to 17 years old presenting to the emergency department with simple, linear facial lacerations requiring repair with sutures were eligible for enrollment.

Validation of magnetic resonance imaging-derived venous oxygen saturation and oxygen consumption measurements during exercise.

Accurate measurement of venous oxygen saturation ([Formula: see text]) is fundamental for quantifying oxygen consumption (V̇o) and its Fick determinants. This study evaluated the validity of a novel magnetic resonance imaging (MRI) approach using susceptometry-based oximetry (SBO) to noninvasively measure [Formula: see text] during exercise. First, [Formula: see text] was measured from an antecubital vein in 14 adults (26 ± 5 yr; 8 males) via portable blood analyzer (iSTAT) at rest and during two 5-min bouts of rhythmic handgrip exercise at 30% of maximum voluntary contraction, with temporally matched SBO measures of [Formula: see text] during an identical in-scanner exercise protocol.

Aorta Wall Stress during Exercise in Patients with an Ascending Thoracic Aortic Aneurysm: Insights from a Case Series.

Individuals with ascending thoracic aortic aneurysm (ATAA) are recommended to avoid intense exercise for fear of marked increases in aortic wall stress (AWS). However, no study has measured AWS during exercise. The aim of this case series was to examine AWS during "light-to-moderate" aerobic exercise in individuals with ATAA and healthy control (CON) participants.

Safety and efficacy of atorvastatin for rebleeding in cerebral cavernous malformations (AT CASH EPOC): a phase 1/2a, randomised placebo-controlled trial.

Background: Cerebral cavernous malformations (CCMs) carry a high risk of rebleeding after symptomatic haemorrhage, with serious clinical sequelae. Atorvastatin was shown to prevent CCM growth and bleeding in animal models. We aimed to assess the safety and efficacy of atorvastatin on rebleeding in patients with CCMs after a symptomatic haemorrhage.

Characterisation of tyre wear particle transport from road runoff to sea in coastal environments.

Data on the fate of tyre wear particles (TWPs) within aquatic environments is limited. This study quantified TWPs entering estuaries in stormwater drainage and atmospheric fallout, and once they have reached the marine environment, within surface waters and sediments. TWPs were found at concentrations of 0.

Citizen science reveals litter trends in the UK: Population density effects on coastal and inland regions.

There is limited understanding of how litter abundance, particularly plastic items, varies between coastal and inland regions with different population densities. The absence of standardised data collection methods further complicates comparisons. Moreover, the lack of data for inland areas hampers efforts to identify potential litter sources, pathways, and interventions.

Surface Modification of Polyesters Using Biosourced Soil-Release Polymers.

Soil-release polymers (SRPs) are important components of fabric care formulations, performing important roles in the cleaning of synthetic fabrics. SRPs modify the surface of textiles and render materials resistant to staining, while offering environmental benefits by enabling effective cleaning using shorter, cooler wash cycles. Most SRPs used in formulations contain petroleum-sourced terephthalic acid, limiting the environmental benefits presented by the use of these key additives.

Cerebral blood flow change with fluid resuscitation in acute ischemic stroke.

Background: In acute ischemic stroke (AIS), cerebral autoregulation becomes dysfunctional, impacting the brain's ability to maintain cerebral blood flow (CBF) at adequate levels. Reperfusion of affected and nearby brain tissue in AIS is currently the aim of treatment in AIS, but the effectiveness of fluid resuscitation on increasing the CBF is debated.

Objective: We investigated the hypothesis that early fluid resuscitation with normal saline bolus would improve CBF velocity in the initial resuscitation of patients with AIS.

Long-term cardiac MRI follow up of MANTICORE (Multidisciplinary Approach to Novel Therapies in Cardio-Oncology REsearch).

Background: This study investigates the long-term cardiac effects of trastuzumab-based chemotherapy in early breast cancer (EBC) survivors. We extend the original MANTICORE trial which showed that angiotensin-converting enzyme inhibitors (ACEI) and beta-blockers (BB) could mitigate the decline in left ventricular (LV) ejection fraction (EF) during the first year of trastuzumab treatment.

Objectives: We hypothesized that, over time, cardiac function would decline further and adverse changes in cardiac geometry would occur due to the aging of the population and prior treatment.

The REpeated ASSEssment of SurvivorS in intracerebral haemorrhage: protocol for a multicentre, prospective observational study.

Background: The REpeated ASSEssment of SurvivorS (REASSESS) study will conduct long-term cognitive, functional and neuropsychiatric performance assessments to determine whether evacuation of spontaneous intracerebral haemorrhage (ICH) reduces the risk of later cognitive decline in the ageing brain.

Methods And Analysis: This study will compare rates of cognitive decline under two treatment strategies for ICH. The first strategy is the use of minimally invasive surgery (MIS) with similar techniques as performed in (1) the Minimally Invasive Surgery plus rt-PA in the Treatment of Intracerebral haemorrhage Evacuation phase III (MISTIE III) trial, (2) the Early MiNimally-invasive Removal of IntraCerebral Haemorrhage (ENRICH) trial and (3) a single-centre cohort of consecutively treated patients with MIS.

The PainSMART project: Protocol for a research program on effectiveness, mechanisms of effect and patient-practitioner experiences of the PainSMART-strategy as an adjunct to usual primary care physiotherapy management for musculoskeletal pain.

Background: Musculoskeletal pain (MSKP) disorders entail a significant burden for individuals and healthcare systems. The PainSMART-strategy has been developed aiming to reduce divergences between patients and healthcare practitioners in their understanding of MSKP by providing a shared basis for communication and to facilitate patients' self-management of MSKP. The objective of the PainSMART-project is to evaluate the effects of the PainSMART-strategy as an adjunct to usual physiotherapy management compared to usual physiotherapy management alone.

Transient Triplet Metallopnictinidenes M-Pn (M = Pd, Pt; Pn = P, As, Sb): Characterization and Dimerization.

Nitrenes (R-N) have been subject to a large body of experimental and theoretical studies. The fundamental reactivity of this important class of transient intermediates has been attributed to their electronic structures, particularly the accessibility of triplet vs singlet states. In contrast, electronic structure trends along the heavier pnictinidene analogues (R-Pn; Pn = P-Bi) are much less systematically explored.

Rationale and design of APOLLO: a personalized rehAbilitation PrOgram in aLLOgeneic bone marrow transplantation.

Background: Hematopoietic stem cell transplantation (HSCT) is a common therapy for many hematologic malignancies. While advances in transplant practice have improved cancer-specific outcomes, multiple and debilitating long term physical and psychologic effects remain. Patients undergoing allogeneic bone marrow transplantation (allo-BMT) are often critically ill at initial diagnosis and with necessary sequential treatments become increasingly frail and deconditioned.

P-P Coupling and Terminal Metal-Phosphorus Intermediates.

Terminal metal-phosphorus (M-P) complexes are of significant contemporary interest as potential platforms for P-atom transfer (PAT) chemistry. Decarbonylation of metal-phosphaethynolate (M-PCO) complexes has emerged as a general synthetic approach to terminal M-P complexes. M-P complexes that are stabilized by strong M-P multiple bonds are kinetically persistent and isolable.