Enhancing water deficit tolerance in canola (Brassica napus L.) through the synergistic application of nano-silicon and sulfur.

Water deficit stress is a critical constraint on global crop productivity, particularly in arid and semi-arid regions, where it severely compromises plant growth, yield, and nutritional quality. Sustainable strategies to enhance plant resilience under such conditions are urgently needed. Nano-silicon (Si-NPs) and sulfur (S) have emerged as promising amendments for mitigating abiotic stress, but their synergistic potential in alleviating water deficit stress in oilseed crops like canola (Brassica napus L.

Innovative microfluidic model for investigating the intestinal mucus barrier: numerical and experimental perspectives.

The intestinal mucus layer serves as a critical first line of defense against external agents, functioning as a barrier to the absorption of drugs, food, and pathogens. While numerous in vitro studies have explored the role of mucus in preventing particle penetration, the effects of flowing luminal material, dislodging of mucus because of induced shear rate by lumen material and interfacial phenomena remain poorly understood. This study introduces a microfluidic approach to simulate the interaction between flowing luminal material and the mucus layer.

Investigation of silicon oxide nanoparticle-enhanced self-healing hydrogel for cartilage repair and regeneration in rabbit earlobe models.

This study developed an alginate, gelatine and chondroitin sulphate hydrogel incorporating silicon oxide nanoparticles to assess hydrogel morphology, cell proliferation and viability. The effectiveness of these hydrogels for cartilage repair was evaluated using male albino rabbits, divided into three groups: a control group without hydrogels, an observer group with hydrogels lacking nanoparticles and a treatment group with nanoparticle-enhanced hydrogels for post-injury repair. At 15, 30 and 60 days post-surgery, the rabbits were humanely euthanized and excised tissue samples were fixed in 10% formalin for histopathological analysis, then processed and embedded in paraffin for microscopic evaluation.

Fabrication, characterization and evaluating properties of 3D printed PLA-Mn scaffolds.

Polylactic acid (PLA) based scaffolds have attained considerable attention in recent years for being used as biodegradable implants in bone tissue engineering (BTE), owing to their suitable biocompatibility and processability. Nevertheless, the mechanical properties, bioactivity and biodegradation rate of PLA need to be improved for practical application. In this investigation, PLA-xMn composite filaments (x = 0, 1, 3, 5 and 7 wt%) were fabricated, characterized, and used for 3D printing of scaffolds by the fused deposition modeling process.

Determination of breast cancer biomarkers with poly acrylic acid/ MIL-88(Fe)-NH hydrogel as a coating for stir bar sorptive extraction.

The Poly acrylic acid/MIL-88(Fe)-NH composite material, carefully prepared, is employed as a sorbent for the stir bar. The best formula of the composite was selected by investigation of two parameters including the cross-linker of PAA and MIL-88(Fe)-NH content. The prepared stir bar was used for extraction of 2-pentanone, 2-heptanone, ethyl propionate, para-xylene, 1,2,4-trimethylbenzene, o-cresol, m-cresol in urine samples as breast cancer biomarkers with gas chromatography-flame ionization detector.

Zinc oxide-aluminum oxide nanocomposite solid phase microextraction for diazepam and oxazepam trace determination.

A new efficient ZnO-AlO nanocomposite (ZANC) was synthesized to form solid-phase microextraction (SPME) fiber. The prepared fiber was used for trace determination of benzodiazepines by gas chromatography-flame ionization detector in urine samples. The effective parameters on the extraction process including extraction time, salt percentage, desorption time and sample pH were optimized by a factorial design method.

Synergistic effect of CaCO addition and in-process cold atmospheric plasma treatment on the surface evolution, mechanical properties, and in-vitro degradation behavior of FDM-printed PLA scaffolds.

The ease of processing and biocompatibility of polylactic acid (PLA) have made it a widely used material for fused deposition modeling (FDM)-based 3D printing. In spite of this, PLA suffers from some limitations for its extensive use in tissue engineering applications, including poor wettability, low degradation rate, and insufficient mechanical properties. To address the previously mentioned limitations, this study examined how combining in-process cold atmospheric plasma treatment with the inclusion of CaCO influences the properties of FDM-printed PLA scaffolds.

Material extrusion additive manufacturing of poly(lactic acid)/Ti6Al4V@calcium phosphate core-shell nanocomposite scaffolds for bone tissue applications.

The use of porous scaffolds with appropriate mechanical and biological features for the host tissue is one of the challenges in repairing critical-size bone defects. With today's three-dimensional (3D) printing technology, scaffolds can be customized and personalized, thereby eliminating the problems associated with conventional methods. In this work, after preparing Ti6Al4V/Calcium phosphate (Ti64@CaP) core-shell nanocomposite via a solution-based process, by taking advantage of fused deposition modeling (FDM), porous poly(lactic acid) (PLA)-Ti64@CaP nanocomposite scaffolds were fabricated.

Improving physio-mechanical and biological properties of 3D-printed PLA scaffolds via in-situ argon cold plasma treatment.

As a bone tissue engineering material, polylactic acid (PLA) has received significant attention and interest due to its ease of processing and biocompatibility. However, its insufficient mechanical properties and poor wettability are two major drawbacks that limit its extensive use. For this purpose, the present study uses in-situ cold argon plasma treatment coupled with a fused deposition modeling printer to enhance the physio-mechanical and biological behavior of 3D-printed PLA scaffolds.

Managing Cancer Treatment in Patients with Renal Dysfunction: The Role of Chemotherapy.

Malignancy is characterized by damage to several vital organs, and utilizing chemotherapy as a treatment option can have toxic effects on healthy body tissues. Kidney function is commonly compromised by cancer and chemotherapy. These effects can be pre-renal, intrarenal, or postrenal.

Teleexercise for geriatric patients with failed back surgery syndrome.

Introduction: Failed back surgery syndrome (FBSS) is defined as back pain which either persists after attempted surgical intervention or originates after a spine surgery. There is a high risk of perioperative morbidity and a high likelihood of extensive revision surgery in geriatric patients with FBSS or post-laminectomy foraminal stenosis.

Methods: There is a need for less invasive methodologies for the treatment of FBSS, such as patient-tailored exercise training, with attention to the cost and special needs of the geriatric patients with FBSS.

Enhanced bone tissue regeneration using a 3D-printed poly(lactic acid)/Ti6Al4V composite scaffold with plasma treatment modification.

The mechanical and biological properties of polylactic acid (PLA) need to be further improved in order to be used for bone tissue engineering (BTE). Utilizing a material extrusion technique, three-dimensional (3D) PLA-Ti6Al4V (Ti64) scaffolds with open pores and interconnected channels were successfully fabricated. In spite of the fact that the glass transition temperature of PLA increased with the addition of Ti64, the melting and crystallization temperatures as well as the thermal stability of filaments decreased slightly.

Additive manufacturing of PLA-Mg composite scaffolds for hard tissue engineering applications.

Polylactic acid (PLA) is considered as a great option to be employed as 3D porous scaffold in hard tissue engineering applications owing to its excellent biocompatibility and processability. However, relatively weak mechanical properties and inappropriate biodegradability limit its extensive usage. In order to overcome the mentioned challenges, micrometric magnesium particles were incorporated into the PLA matrix by the fused deposition modeling (FDM) technique.

Two-way Road of Kidney and Hypercalcemia: A Narrative Review.

Calcium homeostasis is regulated by the dyad of parathyroid hormone and calcitriol, whereas kidney, intestine, and bone are the primary target sites. Elevation of serum calcium levels and hypercalcemia are likely markers of pathological conditions, particularly malignancy and hyperparathyroidism. Similarly, several dysfunctions within the body can direct hypercalcemia.

Understanding the use of oral rehydration therapy: A narrative review from clinical practice to main recommendations.

Background And Aims: Fluid loss due to diarrhea remains a significant cause of mortality among children under the age of 5.

Methods: Oral rehydration therapy (ORT) is a first-line therapeutic measure to compensate the volume loss due to diarrhea and vomiting among gastroenteritis patients. Despite adequate knowledge, the practice of ORT is limited, particularly in developing countries.

Clinical Post-Transplant Lymphoproliferative Disorders.

Post-transplant lymphoproliferative disorders (PTLDs) are characterized by hyperproliferation of B cells due to solid organ or allogeneic hematopoietic stem cell transplant. Based on histological findings, it is divided into 4 categories. Most PTLD patients are Epstein-Barr virus (EBV) positive.

Fabrication of a new SPME fiber based on Polyacrylic acid/ MIL-88(Fe)-NH2 composite as a self-healing coating for the analysis of breast cancer biomarkers in the urine sample.

Analysis of cancer biomarkers in the body fluids is a new method for early detection of illness. However, due to the complex matrices of samples, the application of a pre-treatment method is unavoidable before the final analysis by gas chromatography (GC). Solid-phase microextraction (SPME) is a simple and, promising pre-concentration and separation method that its coatings are modified with different materials on the fibers.

Lead analysis by μSPE/FF-AAS: A comparative study based on dimethylglyoxime functionalized silica-coated magnetic iron/graphene oxides.

Here, four new sorbents based on dimethylglyoxime (DMG) functionalized silica-coated magnetic iron/graphene oxides (FeO/MGO) were synthesized. A comparative study was performed among them to evaluate the different substrates and the role of the spacer in improving the lead extraction efficiency and selecting the most efficient sorbent. Based on experimental results, MGO@SiO@3-chloropropyltrimethoxysilane@DMG was selected for magnetic dispersive μSPE of lead followed by flame (FAAS) and graphite furnace atomic absorption spectroscopy (GFAAS).

Measuring serum sodium levels using blood gas analyzer and auto analyzer in heart and lung disease patients: A cross-sectional study.

Objective: Emergency services require precise and rapid measurement of electrolytes to initiate treatment. Blood gas analyzers (BGA) analyzes blood samples in seconds however, its accuracy is still debatable. The aim of this study was to compare the level of serum sodium measured through BGA and auto analyzer in the laboratory analyzers.

Chronic hemodialysis: Evaluation of dialysis adequacy and mortality.

Objective: Dialysis efficacy is one of the important issues in patients undergoing hemodialysis. This study aimed to determine the adequacy of dialysis with mortality and hospital admissions in patients undergoing hemodialysis.

Methods: This retrospective cohort study was conducted on patients who underwent dialysis.

Prone position: A possible method to decrease post dural puncture headache (PDPH) during surgery.

Objectives: Postdural puncture headache (PDPH) is a complication associated with spinal and epidural anesthesia, characterized by a very severe dull, non-throbbing positional headache along with nausea, vomiting and other symptoms. The aim of this study was to compare positional character of PDPH, where the effects of prone and supine positions during surgery were compared for the risk of the headache.

Methods: This cohort study, was carried out at (XXX) University of Medical Sciences from June 2019 to June 2020 after the approval from the Ethical Committee.

Fabrication of an SPME fiber based on ZnO@GA nanorods coated onto fused silica as a highly efficient absorbent for the analysis of cancer VOCs in water and urine.

Analysis of volatile organic compounds (VOCs) secreted in urine, blood, breath, etc. is a new method for monitoring the metabolism and biochemistry of the human body. However, due to the complexity of samples, a pre-concentration step is necessary before the final analysis with gas chromatography-mass spectroscopy (GC-MS).

Effect of caffeine on postoperative bowel movement and defecation after cesarean section.

Introduction: and Importance: Inadequate bowel movement after cesarean section (C-section) can delay the intake of solid diet. Coffee is reported to have beneficial effects on bowel motility after the surgery. This study is designed to evaluate the effects of coffee on bowel movement and defecation following C-section.