Dual 500-μs wide pulse neuromuscular electrical stimulation enhancing sensorimotor cortical excitability.

Background: Neuromuscular electrical stimulation (NMES) is an effective tool to improve motor activation of patients with motor dysfunction. However, to enhance the cortical activities induced by NMES, the corresponding strategies should be carefully designed with optimal stimulation parameters. The aim of the present study is to investigate whether the pulse assignment with wide-pulse-based Variable Frequency Trains improves sensorimotor cortical excitability.