Second to Fourth Digit Ratio (2D:4D) in Hypertension Disease.

Objectives: The second to fourth digit ratio (2D:4D) is a sexually dimorphic trait thought to reflect prenatal exposure to sex hormones. 2D:4D has been proposed as a potential biomarker for various adult diseases, and evidence suggests that it may also predict cardiovascular disease risk. This study aimed to ascertain the 2D:4D of both hands in patients with hypertension and to determine whether there were any differences between this ratio and that of a control group.

Therapeutic potential of enzymes, neurosteroids, and synthetic steroids in neurodegenerative disorders: A critical review.

Neurodegenerative disorders present a significant challenge to healthcare systems, mainly due to the limited availability of effective treatment options to halt or reverse disease progression. Endogenous steroids synthesized in the central nervous system, such as pregnenolone (PREG), dehydroepiandrosterone (DHEA), progesterone (PROG), and allopregnanolone (ALLO), have been identified as potential therapeutic agents for neurodegenerative diseases. Neurosteroids such as ALLO, DHEA, and PROG, as well as their synthetic analogs like Ganaxolene, Fluasterone, and Olexoxime, offer promising effects for conditions such as Alzheimer's disease (AD) and depression.

Design, synthesis, molecular docking and biological evaluation of new carbazole derivatives as anticancer, and antioxidant agents.

Background: The carbazole skeleton is an important structural motif occurring naturally or synthesized chemically and has antihistaminic, antioxidant, antitumor, antimicrobial, and anti-inflammatory activities.

Objectives: This study aimed to design and synthesize a novel series of carbazole derivatives and evaluate their antiproliferative and antioxidant activities.

Methods: The synthesized compounds were characterized utilizing HRMS, H-, and C-NMR, and assessed for their anticancer, antifibrotic, and antioxidant effects utilizing reference biomedical procedures.