Antioxidant, Antiinflammatory and Antiapoptotic Effects of Lycopene in Rats With Vancomycin-Induced Nephrotoxicity.

Background: The most important side effect of vancomycin (Vanco) is nephrotoxicity (NPT). Lycopene (Lyco) has been reported to have anti-inflammatory and anti-apoptotic properties in addition to its antioxidant activity. The aim is to investigate the protective efficacy of Lyco against the NPT condition that limits the use of Vanco.

Mandarin peel ethanolic extract attenuates diclofenac sodium induced hepatorenal toxicity in rats by mitigating oxidative stress and inflammation.

Nonsteroidal anti-inflammatory drugs (NSAIDs) constitute approximately one-third of the global pharmaceutical market and are the first drugs of choice when treating fever and pain. Furthermore, among NSAIDs, the use of diclofenac sodium (DS) is preferred as it is a strong inhibitor of cyclooxygenase enzyme. However, despite its strong efficacy, DS is known for its potential to cause hepatorenal damage.

Protective effects of polydatin and grape seed extract in rats exposed to cadmium.

The current study aimed to investigate the protective role of polydatin (PD) and grape seed extracts (GSEs) against the effects of cadmium chlorine (CD) application in the rats. Forty-nine adult Wistar albino male rats were used in the study. Rats were assigned into control (saline), CD (5 mg/kg CdCI), PD (120 mg/kg PD), GSE (120 mg/kg GSE), CD + PD (5 mg/kg CdCI + 120 mg/kg PD), CD + GSE (5 mg/kg CdCI + 120 mg GSE), and CD + PD + GSE (5 mg/kg CdCI+120 mg/kg PD +120 mg/kg GSE) treatments ( = 7 per group).

Effects of preoperative magnesium therapy on arrhythmias and myocardial ischemia during off-pump coronary surgery.

Background: Heart manipulation during off-pump coronary artery bypass surgery may cause hemodynamic instability, and temporary coronary arterial occlusion may lead to myocardial ischemia. To reduce this, perioperative β-blocking agents or calcium antagonists can be administrated. The effects of perioperative administration of magnesium on myocardial function were studied in patients undergoing coronary artery bypass grafting.

Determination of some heavy metal levels and oxidative status in Carassius carassius L., 1758 from Eber Lake.

In this study, the levels of some heavy metals (Al, Cd, Co, Cr, Cu, Fe, Li, Mn, Ni, Pb and Zn) in muscle, gill, and liver of Carassius carassius and in the water samples from Eber Lake (Afyonkarahisar, Turkey) have been investigated. Additionally, one of the lipid peroxidation markers, malondialdehide (MDA) and glutathion (GSH) levels were investigated. All the metal analysis was performed by using ICP-AES.

Permanent pacemaker lead implantation via azygous vein in a patient with silent superior vena cava syndrome.

Occlusion of the superior vena cava is a rare but serious complication of transvenous endocardial pacing. We describe an unusual approach for permanent pacemaker implantation using the azygous vein in a patient with occlusion of the bilateral total subclavian and innominate veins after previous bilateral pectoral pacemaker implantation. Endocardial pacing using the azygous vein with minimal invasive thoracotomy may be a good option for patients with inaccessible subclavian route.

Transesophageal echocardiographic diagnosis of ventricular noncompaction associated with an atrial septal aneurysm in a patient with dilated cardiomyopathy of unknown etiology.

The present report discusses a case of noncompaction of the ventricular myocardium in a 51-year-old woman with dilated cardiomyopathy of unknown etiology. Multiple transthoracic echocardiography examinations had failed to show myocardial noncompaction, but subsequently performed transesophageal echocardiography clearly demonstrated the characteristic findings of this unusual disease. Also, an atrial septal aneurysm was identified by transesophageal echocardiography.

Role of endogenous adenosine in atrial fibrillation after coronary artery bypass graft.

Background: Atrial fibrillation (AF) is the most common complication following coronary artery bypass graft (CABG). The mechanism of AF after CABG is not well defined; however, it is suggested that endogenous adenosine, released in response to tissue hypoxia, may play a mechanistic role in these arrhythmias.

Hypothesis: The purpose of this study was to examine whether intravenous theophylline, via adenosine A1 receptor antagonism, would correct or modify new-onset early (<48 h post CABG) atrial fibrillation in patients post CABG, and thereby implicate endogenous adenosine as an inciting agent.

[The effect of glutamate and aspartate on myocardial protection at cardiopulmonary bypass].

Objective: To determine whether glutamat and aspartat enriched cold crystalloid cardioplegia which was given in antegrade way has any effect on the myocardial protection during cardiopulmonary bypass.

Methods: Thirty-four patients who were electively undergone open heart surgery at Osmangazi University Faculty of Medicine, thoracic and cardiovascular surgery department, between March 2001 and May 2001 were included in this study. The patients were divided in two groups, each consisting of 17 patients.

[Experiments on minimally invasive open heart surgery using right anterolateral minithoracotomy].

Objective: Minimal invasive cardiac surgical techniques recently have been applied in the management of various cardiac lesions. The aim of the study was to evaluate right anterolateral minithoracotomy as an alternative procedure with a better cosmetic and clinical outcomes.

Methods: Fifteen male and 64 female patients underwent open heart surgery during cardiopulmonary bypass through a right anterolateral minithoracotomy at the fourth intercostal space.

Traumatic total occlusion of left main coronary artery caused by blunt chest trauma.

Myocardial infarction is a rare complication that can occur immediately after a blunt chest trauma. We report a 36-year-old male who experienced a fatal anterolateral myocardial infarction after a nonpenetrating chest injury sustained in a car accident. Injuries of the coronary arteries associated with blunt chest trauma predominantly affect the left anterior descending artery.