Procurement of Parathyroid Glands from Living Donor Pigs and Ex Vivo Identification.

Hypoparathyroidism, often resulting from surgical complications, severely disrupts calcium homeostasis, leading to disabling symptoms. Current treatments offer limited relief, highlighting the need for alternative therapies like parathyroid transplantation. This study introduces a simple method for living-donor parathyroid procurement from pigs, with potential applications in transplantation research, especially for the field of xenotransplantation.

Pig Models in Translational Surgery.

Background: Because rodents are too small to perform surgical procedures on people, large mammals are frequently required for surgical studies. Because of its similar overall anatomy and physiology, the pig has a very high translational value and is thus frequently used as the first choice in surgical research.

Summary: In cardiovascular treatments, it helped design stents, improve coronary bypass grafting, and perform heart valve xenotransplants.

Genetic Evidence of Causal Relation Between Intestinal Glucose Absorption and Early Postprandial Glucose Response: A Mendelian Randomization Study.

The postprandial glucose response is an independent risk factor for type 2 diabetes. Observationally, early glucose response after an oral glucose challenge has been linked to intestinal glucose absorption, largely influenced by the expression of sodium-glucose cotransporter 1 (SGLT1). This study uses Mendelian randomization (MR) to estimate the causal effect of intestinal SGLT1 expression on early glucose response.

Effects of subtotal pancreatectomy and long-term glucose and lipid overload on insulin secretion and glucose homeostasis in minipigs.

Introduction: Nowadays, there are no strong diabetic pig models, yet they are required for various types of diabetes research. Using cutting-edge techniques, we attempted to develop a type 2 diabetic minipig model in this study by combining a partial pancreatectomy (Px) with an energetic overload administered either orally or parenterally.

Methods: Different groups of minipigs, including Göttingen-like (GL, n = 17) and Ossabaw (O, n = 4), were developed.

Long-Term Analgesia following a Single Application of Fentanyl Transdermal Solution in Pigs.

Introduction: In animal research, obtaining efficient and constant pain control is regulatory but challenging. The gold standard pain management consists of opioid analgesic administration, such as buprenorphine or fentanyl extended-release patches. However, as in all drugs with a short half-life time, repeated buprenorphine administrations are needed, leading to multiple injections that affect the research protocol.