Epigenome-wide association study identifies a specific panel of DNA methylation signatures for antenatal and postpartum depressive symptoms.

Depression during pregnancy and postpartum poses significant risks to both maternal and child well-being. The underlying biological mechanisms are unclear, but epigenetic variation could be exploited as a plausible candidate for early detection. We investigated whether DNA methylation signatures are associated with antenatal depressive symptoms (ADS) and whether early alterations in methylation patterns could be used to predict postpartum depressive symptoms (PDS).

Complex case of acute mesenteric ischemia in a patient with atrial fibrillation: A radiologic -surgical collaboration for timely intervention.

Acute mesenteric ischemia (AMI), often caused by embolic events in patients with atrial fibrillation (AF), can lead to bowel necrosis without timely intervention. This study evaluated the role of CT angiography (CTA) in diagnosing AMI and its impact on surgical outcomes through radiologic-surgical collaboration in 100 AF patients. CTA demonstrated a high diagnostic accuracy, correctly identifying AMI in 92% of cases (p < 0.

Association of early pregnancy telomere length and mitochondrial copy number with gestational diabetes mellitus and depressive symptoms.

Aim: A bidirectional link exists between depression and gestational diabetes mellitus (GDM). While telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN) alterations have been reported either in GDM or depression, their predictive ability of GDM with coexisting depression remains unexplored. We, therefore, prospectively investigated the relationship of TL and mtDNA-CN in blood leukocytes during early pregnancy and explored their potential as predictive biomarkers for identifying the risk of developing GDM with depressive symptoms later in pregnancy.