Biochemical profiling and structural basis of ADAR1-mediated RNA editing.

ADAR1 regulates RNA-induced immune responses by converting adenosine to inosine in double-stranded RNA. Mutations in ADAR1 are associated with human autoimmune disease, and targeting ADAR1 has been proposed for cancer immunotherapy. However, the molecular mechanisms underlying ADAR1-mediated editing remain unclear.

Deficiency of m A RNA methylation promotes ZBP1-mediated cell death.

m A RNA methylation suppresses the immunostimulatory potential of endogenous RNA. Deficiency of m A provokes inflammatory responses and cell death, but the underlying mechanisms remain elusive. Here we showed that the noncoding RNA 7SK gains immunostimulatory potential upon m A depletion and subsequently activates the RIG-I/MAVS axis to spark interferon (IFN) signaling cascades.

Linking D-Dimer and haematological parameters among Indian COVID 19 patients.

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak continues to place a significant strain on healthcare systems, economies, and patient management. Therefore, it is of interest to evaluate the role of D-Dimer and haematological parameters to identify severity and outcome of COVID 19 patients. Total 100 cases diagnosed with COVID 19 were recruited in the study and followed up for 6 months.

Leukemia cutis in a patient of relapsed leprosy- Coincidence or predisposition?

Leprosy, a disease of skin and peripheral nerves has varied manifestations which principally affect the immune status of the host. Leukemic skin infiltrations in patients with leukemia are referred to as leukemia cutis. It can be seen in all types of leukemia, especially in patients with acute myelomonocytic leukemia (AML).