Publications by authors named "Raquel Gil-Laborda"
Introduction: Reproductive immunology has advanced significantly, recognizing the immune system as crucial in pregnancy development and facilitating the identification of abnormalities causing recurrent reproductive failure, as well as proposing targeted treatments for these patients.
Methods: This is a descriptive, observational, and retrospective study conducted at the Reproductive Immunology Unit of the Hospital Clínico San Carlos in Madrid. Clinical and analytical data were analyzed for patients diagnosed with recurrent reproductive failure between 2019 and 2023.
Article Synopsis
- A study on 173 female patients with recurrent reproductive failure (RRF) found a notably higher prevalence of HLA genes associated with celiac disease (CD) and non-celiac gluten sensitivity (NCGS), compared to the general population (69% vs. 35%-40%).
- Only a small percentage (2.3%) of the patients were diagnosed with CD, but those with HLA genetic susceptibility showed a significant link to higher rates of hypothyroidism (48.7% vs. 26.92%).
- Patients with both HLA susceptibility and thyroid disease had better pregnancy outcomes when on a gluten-free diet and using levothyroxine, indicating potential benefits of these interventions for reproductive success.
Throughout pregnancy, the decidua is predominantly populated by NK lymphocytes expressing Killer immunoglobulin-like receptors (KIR) that recognize human leukocyte antigen-C (HLA-C) ligands from trophoblast cells. This study aims to investigate the association of KIR-HLA-C phenotypes in couples facing infertility, particularly recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF), in comparison to a reference population and fertile controls. This observational, non-interventional retrospective case-control study included patients consecutively referred to our Reproductive Immunology Unit from 2015 to 2019.
View Article and Find Full Text PDFMyeloid-derived suppressor cells as a potential biomarker for recurrent pregnancy loss and recurrent implantation failure: Increased levels of MDSCs in recurrent reproductive failure.
Am J Reprod Immunol
November 2023
Problem: Recurrent pregnancy loss (RPL) and recurrent implantation failure (RIF) represent distinct clinical conditions with established definitions, both of which have been linked to an underlying pro-inflammatory state. This study aimed to explore the levels of monocytic-myeloid-derived suppressor cells (M-MDSCs) and regulatory T cells (T ) in a cohort of RPL and RIF women and their potential contribution to RPL and RIF.
Method Of Study: One hundred and eight non-pregnant women were evaluated: 40 RPL, 41 RIF, and 27 fertile healthy controls (HC).