Publications by authors named "Rapi Nteene"
Background: RSV/ΔNS2/Δ1313/I1314L (RSVt) (Sanofi) is a candidate live-attenuated intranasal respiratory syncytial virus (RSV) vaccine for infants and toddlers.
Methods: This phase I/II randomized clinical trial, conducted at sites in the United States (N=22), Chile (N=2), and Honduras (N=2), enrolled participants 6-18 months of age in four cohorts. In cohort 4, the primary cohort reported in this article, participants were randomly assigned to receive vaccinations on days 0 and 56 of either low-dose (LD) RSVt, high-dose (HD) RSVt, or placebo.
Article Synopsis
- - A study was conducted to evaluate the safety and effectiveness of nirsevimab, a monoclonal antibody, in preventing hospitalizations due to respiratory syncytial virus (RSV) in healthy infants during their first RSV season.
- - Infants aged 12 months or younger who were born at least 29 weeks gestation were randomly assigned to receive either nirsevimab or standard care, with results showing that 0.3% in the nirsevimab group were hospitalized compared to 1.5% in the standard-care group, indicating an 83.2% efficacy for nirsevimab.
- - The study also found that severe cases of RSV were less common in the nirsevimab