Automated Morphologic Differentiation Between Iron Deficiency Anemia and Thalassemia.

Background: Iron deficiency anemia (IDA) and hemoglobinopathies (HbP) are two frequent conditions characterized by microcytemia. Published criteria/scores discriminating these conditions with hematology analyzer parameters are not fully satisfactory. Although patients with HbP have been reported to have more red blood cells (RBC) with a target cell (TC) morphology than patients with IDA, obtaining TC percentages remains a time-consuming task since at least 1000 RBC must be examined.

Exploring the performance of an artificial intelligence- and morphology-driven workflow integrating 4 platelet enumeration technologies.

Objective: Platelet count, one of the main parameters of the complete blood count, requires accurate evaluation to guide patient management. It can be hampered by EDTA-induced pseudo-thrombocytopenia (PTCP), microcytic red blood cells (RBCs), RBC fragments, or giant platelets. A new set of 4 methods from the Mindray CAL-8000 platform, applicable on a single sample for platelet count, was evaluated.

The Role of New Morphological Parameters Provided by the BC 6800 Plus Analyzer in the Early Diagnosis of Sepsis.

Background: Late diagnosis of sepsis is associated with adverse consequences and high mortality rate. The aim of this study was to evaluate the diagnostic value of hematologic research parameters, that reflect the cell morphology of blood cells, available on the BC 6800 plus automated analyzer (Mindray) for the early detection of sepsis.

Materials And Methods: A complete blood count (CBC) was performed by Mindray BC 6800 Plus Analyzer in 327 patients (223 with a confirmed diagnosis of sepsis following sepsis-3 criteria, 104 without sepsis), admitted at the Intensive Care Unit of the Novara's Hospital (Italy) and in 56 patients with localized infection.

Preliminary evaluation of a new flow cytometry method for the routine hematology workflow.

Background In a generalist laboratory, the integration of the data obtained from hematology analyzers (HAs) with those from multiparametric flow cytometry (FMC) could increase the specificity and sensitivity of first level screening to identify the pathological samples. The aim of this study was to perform a preliminary evaluation of a new simple hybrid method (HM). The method was obtained by integration between HAs reagents into FCM, with a basic monoclonal antibodies panel for the leukocytes differential count.

A Preliminary Proposal for Quality Control Assessment and Harmonization of Leukocytes Morphology-structural Parameters (cell Population Data Parameters).

Background: The cell population data (CPD) measured by Sysmex XN-9000 can be used for screening many hematological and non-hematological disorders. Since little information is available on harmonization of CPD among different instrumentation and clinical laboratories, this study aimed at assessing the current degree of CPD harmonization between separate Sysmex XN modules allocated to the same laboratory.

Methods: A total number of 78291 data were used for verification of within-run imprecision, analyzers harmonization, reference ranges and assessment of blood sample stability of CPD parameters, including results of daily quality control testing and those generated in samples collected from blood donors and healthy volunteers.

Evidence for tissue iron overload in long-term hemodialysis patients and the impact of withdrawing parenteral iron.

Background/aims: Erythropoiesis in long-term hemodialyzed (LTH) patients is supported by erythropoietin (rHuEpo) and intravenous (IV) iron. This treatment may end up in iron overload (IO) in major organs. We studied such patients for the parameters of IO in the serum and in major organs.

Decreased mean sphered cell volume values in top-level rugby players are related to the intravascular hemolysis induced by exercise.

Sports anemia is a common risk for athletes. Intravasclar hemolysis is the principal source of an accelerated turnover of erythrocytes in sportsmen. The hemolysis induces some biochemical and hematological modifications; in particular, high concentrations of total and indirect (unconjugated) bilirubin could be reported in professional athletes.