Effects of Caffeine Supplementation on Neuromuscular Performance in Powerlifting Athletes: A Randomized, Placebo-Controlled, Quadruple-Blinded, Cross-Over Study.

Enes, A, Hubner, P, Oneda, G, Bernardo, MF, Macedo, ACG, Salles, GN, Ferreira, LHB, Rezende, EF, Mohan, AE, Piñero, A, Leonel, DF, Cruz, R, Schoenfeld, BJ, and Souza-Junior, TP. Effects of caffeine supplementation on neuromuscular performance in powerlifting athletes: a randomized, placebo-controlled, quadruple-blinded, cross-over study. J Strength Cond Res XX(X): 000-000, 2025-This study investigated the effects of caffeine supplementation (CAF) on neuromuscular performance and rating of perceived exertion (RPE) in powerlifting athletes.

Particle deposition and exercise: further understanding beyond the intensity and duration of the task.

This study aimed to quantify and compare the total and anatomical regions of fine particulate matter (PM) deposition in the human respiratory tract during endurance moderate exercise (EndME), endurance interval exercise (EndIE), and resistance exercise (RTE). A mathematical modeling-based analysis on anatomical and physiological characteristics of the human respiratory tract was conducted. The Monte Carlo method was performed to randomly generate different values of minute ventilation (ranging from 95% CI upper and lower) for simulated training sessions of 60 minutes for EndME and RTE, and 20 minutes for EndIE.

Does traffic-related air pollution exposure alter blood gas parameters in recreationally trained male cyclists during prolonged endurance exercise?

Exposure to air pollution has been a significant challenge in large cities as São Paulo, Brazil, particularly for individuals exercising outdoors. The increasing on ventilation (VE) during physical effort can lead to greater pollutant inhalation. Our goal in the present study evaluated whether air pollution exposure affects venous blood gases and if it has an impact on performance during a 50-km cycling time trial (TT).

Self-Catalyzed Chemically Coalescing Liquid Metal Emulsions.

Gallium-based liquid metal alloys (GaLMAs) have widespread applications ranging from soft electronics, energy devices, and catalysis. GaLMAs can be transformed into liquid metal emulsions (LMEs) to modify their rheology for facile patterning, processing, and material integration for GaLMA-based device fabrication. One drawback of using LMEs is reduced electrical conductivity owing to the oxides that form on the surface of dispersed liquid metal droplets.

The blood serum metabolome profile after different phases of a 4-km cycling time trial: Secondary analysis of a randomized controlled trial.

It has been assumed that exercise intensity variation throughout a cycling time trial (TT) occurs in alignment of various metabolic changes to prevent premature task failure. However, this assumption is based on target metabolite responses, which limits our understanding of the complex interconnection of metabolic responses during exercise. The current study characterized the metabolomic profile, an untargeted metabolic analysis, after specific phases of a cycling 4-km TT.

Multiscale Heterogeneous Polymer Composites for High Stiffness 4D Printed Electrically Controllable Multifunctional Structures.

4D printing is an emerging field where 3D printing techniques are used to pattern stimuli-responsive materials to create morphing structures, with time serving as the fourth dimension. However, current materials utilized for 4D printing are typically soft, exhibiting an elastic modulus (E) range of 10 to 10 MPa during shape change. This restricts the scalability, actuation stress, and load-bearing capabilities of the resulting structures.

Comparación de las características epidemiológicas, clínicas y quirúrgicas de pacientes con y sin recidiva de hernias inguinales operados en el Centro Médico Naval.

Background: Recurrent inguinal hernia is currently considered a complex hernia of the abdominal wall after it has been managed with a primary procedure, which represents a more technically challenging hernia.

Objective: To determine the difference in epidemiological, clinical and surgical characteristics of patients with recurrent inguinal hernia and patients without recurrence.

Method: Analytical cross-sectional study, in people over 18 years of age after surgery for inguinal hernia at the Naval Medical Center during the period from July 1, 2016 to June 30, 2019, integrating two study groups.

Effects of air pollution exposure on inflammatory and endurance performance in recreationally trained cyclists adapted to traffic-related air pollution.

The aim of the present study was to analyze the effects of traffic-related air pollution (TRAP) on markers of inflammatory, neuroplasticity, and endurance performance-related parameters in recreationally trained cyclists who were adapted to TRAP during a 50-km cycling time trial (50-km cycling TT). Ten male cyclists performed a 50-km cycling TT inside an environmental chamber located in downtown Sao Paulo (Brazil), under TRAP or filtered air conditions. Blood samples were obtained before and after the 50-km cycling TT to measure markers of inflammatory [interleukin-6 (IL-6), C-reactive protein (CRP), interleukin-10 (IL-10), intercellular adhesion molecule-1 (ICAM-1)] and neuroplasticity [brain-derived neurotrophic factor (BDNF)].

Air pollution and high-intensity interval exercise: Implications to anti-inflammatory balance, metabolome and cardiovascular responses.

High-intensity interval exercise (HIIE) is an effective non-pharmacological tool for improving physiological responses related to health. When HIIE is performed in urban centers, however, the exerciser is exposed to traffic-related air pollution (TRAP), which is associated with metabolic, anti-inflammatory imbalance and cardiovascular diseases. This paradoxical combination has the potential for conflicting health effects.

Traffic-related air pollution and endurance exercise: Characterizing non-targeted serum metabolomics profiling.

Although the exposure to traffic-related air pollution (TRAP) has emerged as one of main problem worldwide to inhabitants' health in urban centers, its impact on metabolic responses during exercise is poorly understood. The aim of study was to characterize the profile of non-target serum metabolomics during prolonged exercise performed under TRAP conditions. Ten healthy men completed two 90 min constant-load cycling trials under conditions of either TRAP or filtered air.

Exercising under particulate matter exposure: Providing theoretical support for lung deposition and its relationship with COVID-19.

The aim of the present study was to investigate lung particulate matter (PM) deposition during endurance exercise and provide a new insight concerning how SARS-CoV-2 could be carried into the respiratory tract. The anatomical and physiological characteristics of the Human Respiratory Tract model were considered for modeling the lung PM deposition during exercise. The Monte Carlo method was performed to randomly generate different values of PM concentrations (1.

Distinct pacing profiles result in similar perceptual responses and neuromuscular fatigue development: Why different "roads" finish at the same line?

The current study analysed the effect of distinct pacing profiles (i.e. U, J, and inverted J) in the perceptual responses and neuromuscular fatigue (NMF) development following a 4-km cycling time trial (TT).

Effects of induced local ischemia during a 4-km cycling time trial on neuromuscular fatigue development.

The present study analyzed the effects of local ischemia during endurance exercise on neuromuscular fatigue (NMF). Nine cyclists performed, in a counterbalanced order, two separate 4-km cycling time trials (TT) with (ISCH) or without (CONTR) induced local ischemia. NMF was characterized by using isometric maximal voluntary contractions (IMVC), whereas central [voluntary activation (VA)] and peripheral fatigue [peak torque of potentiated twitch (TwPt)] of knee extensors were evaluated using electrically evoked contractions performed before (PRE) and 1 min after (POST) the TT.

Exercising in the urban center: Inflammatory and cardiovascular effects of prolonged exercise under air pollution.

The aim of this study was to investigate, in a well-controlled experimental environment, whether air pollution from an urban center would affect inflammatory and cardiorespiratory responses during prolonged moderate exercise (i.e., 90 min).

Determinant Factors of the Match-Based Internal Load in Elite Soccer Players.

: To analyze the contribution of physical measures and external load in the match-based internal load of elite soccer players. : Twenty-three elite soccer players (n = 23, age 26.69 ± 3.

Estimation of minute ventilation by heart rate for field exercise studies.

The aim of this study was to develop predictive equations for minute ventilation based on heart rate, and to test the precision of the equations in two forms of endurance exercise. Eighteen men (age 27.8 ± 5.

Pre-planned Vs. Executed Real-Time Pacing Strategies during 3-km Race: Role of Rating Perceived Exertion.

: The aim of the study was to verify the agreement between preplanned and executed pacing during a 3-km race and determine whether adjustments are mediated by the rating of perceived exertion (RPE). : Thirteen young runners (eight males and five females, 17.5 ± 2.

Safety, tolerability, and response rates of daratumumab in relapsed AL amyloidosis: results of a phase 2 study.

Daratumumab, a monoclonal CD38 antibody, is approved in the treatment of myeloma, but its efficacy and safety in light-chain (AL) amyloidosis has not been formally studied. This prospective phase 2 trial of daratumumab monotherapy for the treatment of AL amyloidosis was designed to determine the safety, tolerability, and hematologic and clinical response. Daratumumab 16 mg/kg was administered by IV infusion once weekly for weeks 1 to 8, every 2 weeks for weeks 9 to 24, and every 4 weeks thereafter until progression or unacceptable toxicity, for up to 24 months.

Characterization of performance fatigability during a self-paced exercise.

Pacing during a high-intensity cycling time trial (TT) appears to prevent premature task failure, but the performance fatigability during a self-paced exercise is currently unknown. Therefore, the current study characterized the time course of performance fatigability during a 4-km TT. Eleven male cyclists performed three separated TTs in a crossover, counterbalanced design.

Exercising in Air Pollution: The Cleanest versus Dirtiest Cities Challenge.

: Aerobic exercise is recommended to improve health. However, the increased ventilation might increase the doses of inhaled air pollutants, negating the health benefits in highly polluted areas. Our objective was to estimate the inhaled dose of air pollutants during two simulated exercise sessions at cleanest and dirtiest cities reported by World Health Organization (WHO) considering air quality.

Permanent Cerebellar Degeneration After Acute Hyperthermia with Non-toxic Lithium Levels: a Case Report and Review of Literature.

This was a study of a 33-year-old man with bipolar disorder treated with lithium who developed cerebellar atrophy after an event of extreme hyperthermia. Unlike previously reported cases of acute cerebellar atrophy after heat stroke, neuroleptic syndrome or lithium toxicity, this case was characterized by a chronic cerebellar atrophy that developed after sepsis-induced hyperthermia in the setting of non-toxic lithium levels. Unique to this case also was the early finding of cerebellar atrophy on MRI 2 weeks after the episode of hyperthermia, long-term neurotoxicity after the novo lithium therapy, and longest follow-up case of chronic cerebellar syndrome after hyperthermia with non-toxic lithium levels.

Factors determining 800-m running performance in young male athletes.

BACKGROUNDː The aim of the present study was to identify determinant variables on 800-m running performance in young male athletes derived from field tests and biological maturity. METHODSː A total of 89 athletes, aged between 13 and 15 years old, performed a 800-m running trial and a battery of tests which involved anthropometric measurements, a running anaerobic test (RAST), a flexibility test (sit-and-reach), a counter movement jump test and progressive test for aerobic fitness evaluation. A stepwise multiple regression model selected three independent variables to explain the variance in 800-m running performance trial: peak of aerobic speed (PAS), total time of all sprints (RAST) and predicted mature stature (PMS).

Health Vulnerability Index and newborn hearing screening: urban inequality.

Purpose: To analyze the intra-urban differentials related to the outcome of the Newborn Hearing Screening (NHS) of children living in Belo Horizonte tested in a reference service using the Health Vulnerability Index (HVI).

Methods: cross-sectional study with children living in Belo Horizonte evaluated by a Newborn Hearing Screening Reference Service (NHSRS) between 2010 and 2011. The HVI of the census tract of each child was obtained by the georeferencing of their respective addresses.

Outcome of tuberculosis treatment: a comparison between Alberta and Nicaragua.

Objective: To measure the outcome of tuberculosis treatment in a low incidence, high income region, Alberta, and compare with an intermediate incidence, low income country with a model national tuberculosis program, Nicaragua.

Design: All 1992 sputum smear-positive pulmonary cases from both regions were included. Treatment outcome was assigned retrospectively to Alberta cases according to the International Union Against Tuberculosis and Lung Diseases' (IUATLD) criteria of cure, failure, transfer, absconder and death.