Association between Depressive Symptom Trajectory and Chronic Kidney Disease Progression: Findings from the Chronic Renal Insufficiency Cohort Study.

Key Points: Depressive symptoms are largely stable over time among individuals with mild-to-moderate CKD. Low educational attainment, cigarette smoking, and poor quality of life are associated with persistent depressive symptoms. Persistent depressive symptoms are associated with nonlinear and rapid decline in kidney function.