Comparison of Spontaneous Breathing Versus Paralyzed Technique During Flexible Bronchoscopic Intubation in Anesthetized Children and Adolescents With Temporomandibular Joint Ankylosis: Randomized Parallel Group Trial.

Background: Literature is sparse on airway management in temporomandibular joint ankylosis patients, and it is not known whether spontaneous or paralyzed technique of intubation will be better for flexible bronchoscopic intubation.

Aim: To compare the incidence of difficult flexible bronchoscopic intubation between the spontaneously breathing and paralyzed groups in anesthetized children and adolescents.

Methods: In this Randomized parallel group study, after ethics committee approval and trial registration, we enrolled 70 children and adolescents up to 18 years with temporomandibular joint ankylosis and mouth opening < 1.

Prophylactic Melatonin for Delirium in Intensive Care Unit: An Updated Systematic Review and Meta-analysis of Randomized Controlled Trials.

Introduction: Delirium, being a common disorder among critically ill patients, has a reported incidence ranging 45-83% in the intensive care unit (ICU) population. The prophylactic use of melatonin and melatonergics has been shown to have a positive effect in reducing the incidence of delirium in many clinical trials. Our study was thus proposed to find out the role of melatonin on the incidence and severity of ICU delirium, ICU and hospital length of stay (LOS), requirement, duration of mechanical ventilation, and ICU mortality.