Corrigendum: Characterization of Spp. Inciting Vascular Wilt of Tomato and Its Management by a -Based Biocontrol Consortium.

[This corrects the article DOI: 10.3389/fpls.2021.

CNViz: An R/Shiny Application for Interactive Copy Number Variant Visualization in Cancer.

Copy number variants (CNVs) comprise a class of mutation which includes deletion, duplication, or amplification events that range in size from smaller than a single-gene or exon, to the size of a full chromosome. These changes can affect gene expression levels and are thus implicated in disease, including cancer. Although a variety of tools and methodologies exist to detect CNVs using data from massively parallel sequencing (also referred to as next-generation sequencing), it can be difficult to appreciate the copy number profile in a list format or as a static image.

Visual association cortex links cues with conjunctions of reward and locomotor contexts.

Postrhinal cortex (POR) and neighboring lateral visual association areas are necessary for identifying objects and interpreting them in specific contexts, but how POR neurons encode the same object across contexts remains unclear. Here, we imaged excitatory neurons in mouse POR across tens of days prior to and throughout initial cue-reward learning and reversal learning. We assessed responses to the same cue when it was rewarded or unrewarded, during both locomotor and stationary contexts.

The role of lattice dynamics in ferroelectric switching.

Reducing the switching energy of ferroelectric thin films remains an important goal in the pursuit of ultralow-power ferroelectric memory and logic devices. Here, we elucidate the fundamental role of lattice dynamics in ferroelectric switching by studying both freestanding bismuth ferrite (BiFeO) membranes and films clamped to a substrate. We observe a distinct evolution of the ferroelectric domain pattern, from striped, 71° ferroelastic domains (spacing of ~100 nm) in clamped BiFeO films, to large (10's of micrometers) 180° domains in freestanding films.

Isolation and biological evaluation 7-hydroxy flavone from L: insights from extensive , DFT, molecular docking and molecular dynamics simulation studies.

The flavonoid based 7-hydroxy flavone (PubChem CID: 5281894; molecular formula: CHO) molecule has been isolated for the first time from the methanolic extract from the leaves of L. in the tropical mangrove ecosystem of Andaman and Nicobar Islands (ANI), India. The molecular structure of bioactive compound was characterized by spectroscopic analysis, including FT-IR, H, C NMR spectroscopy and ESI-HRMS and elucidated as 7-hydroxy flavone.

Organically derived exosomes as carriers of anticancer drugs and imaging agents for cancer treatment.

Extracellular vesicles (EVs), is the umbrella term used for different types of vesicles produced by the cells, among which exosomes form the largest group. Exosomes perform intercellular communication by carrying several biologics from donor or parental cells and delivering them to recipient cells. Their unique cargo-carrying capacity has recently been explored for use as delivery vehicles of anticancer drugs and imaging agents.

Ferroelectricity in a semiconducting all-inorganic halide perovskite.

Ferroelectric semiconductors are rare materials with both spontaneous polarizations and visible light absorptions that are promising for designing functional photoferroelectrics, such as optical switches and ferroelectric photovoltaics. The emerging halide perovskites with remarkable semiconducting properties also have the potential of being ferroelectric, yet the evidence of robust ferroelectricity in the typical three-dimensional hybrid halide perovskites has been elusive. Here, we report on the investigation of ferroelectricity in all-inorganic halide perovskites, CsGeX, with bandgaps of 1.

Liberating a hidden antiferroelectric phase with interfacial electrostatic engineering.

Antiferroelectric materials have seen a resurgence of interest because of proposed applications in a number of energy-efficient technologies. Unfortunately, relatively few families of antiferroelectric materials have been identified, precluding many proposed applications. Here, we propose a design strategy for the construction of antiferroelectric materials using interfacial electrostatic engineering.

Stimulus-Induced Narrowband Gamma Oscillations are Test-Retest Reliable in Human EEG.

Visual stimulus-induced gamma oscillations in electroencephalogram (EEG) recordings have been recently shown to be compromised in subjects with preclinical Alzheimer's Disease (AD), suggesting that gamma could be an inexpensive biomarker for AD diagnosis provided its characteristics remain consistent across multiple recordings. Previous magnetoencephalography studies in young subjects have reported consistent gamma power over recordings separated by a few weeks to months. Here, we assessed the consistency of stimulus-induced slow (20-35 Hz) and fast gamma (36-66 Hz) oscillations in subjects ( = 40) (age: 50-88 years) in EEG recordings separated by a year, and tested the consistency in the magnitude of gamma power, its temporal evolution and spectral profile.

Emergent interface vibrational structure of oxide superlattices.

As the length scales of materials decrease, the heterogeneities associated with interfaces become almost as important as the surrounding materials. This has led to extensive studies of emergent electronic and magnetic interface properties in superlattices. However, the interfacial vibrations that affect the phonon-mediated properties, such as thermal conductivity, are measured using macroscopic techniques that lack spatial resolution.

Compact glyoxal tanning system: a chrome-free sustainable and green approach towards tanning-cum-upgradation of low-grade raw materials in leather processing.

Increased concern over the use of metal salts such as chromium, zirconium, and aluminum for tanning of hides and skins has made the leather production industry to be constantly on the lookout for organic tanning agents in place of the inorganic system. Though glutaraldehyde has been looked at as a viable option, it still lags in imparting superior strength properties to the leather and also it has been reported to have inherent toxicity. With that concept in view, this research work focuses on the usage of glyoxal along with synthetic tanning agents as a replacement for glutaraldehyde and other inorganic tanning systems.

In Vitro and In Vivo Inhibition of the Phosphopantetheinyl Transferase PptT by Amidinoureas.

A newly validated target for tuberculosis treatment is phosphopantetheinyl transferase, an essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence factors in . The structure-activity relationships of a recently disclosed inhibitor, amidinourea (AU) 8918 (), were explored, focusing on the biochemical potency, determination of whole-cell on-target activity for active compounds, and profiling of selective active congeners. These studies show that the AU moiety in AU 8918 is largely optimized and that potency enhancements are obtained in analogues containing a para-substituted aromatic ring.

Neuronally-enriched exosomal microRNA-27b mediates acute effects of ibuprofen on reward-related brain activity in healthy adults: a randomized, placebo-controlled, double-blind trial.

This double-blind, randomized, within-subjects design evaluated whether acute administration of an anti-inflammatory drug modulates neuron-specific, inflammation-modulating microRNAs linked to macroscopic changes in reward processing. Twenty healthy subjects (10 females, 10 males) underwent a functional magnetic resonance imaging scan while performing a monetary incentive delay (MID) task and provided blood samples after administration of placebo, 200 mg, or 600 mg of ibuprofen. Neuronally-enriched exosomal microRNAs were extracted from serum and sequenced.

Materials for a Sustainable Microelectronics Future: Electric Field Control of Magnetism with Multiferroics.

This article is written on behalf of many colleagues, collaborators, and researchers in the field of complex oxides as well as current and former students and postdocs who continue to enable and undertake cutting-edge research in the field of multiferroics, magnetoelectrics, and the pursuit of electric-field control of magnetism. What I present is something that is extremely exciting from both a fundamental science and applications perspective and has the potential to revolutionize our world, particularly from a sustainability perspective. To realize this potential will require numerous new innovations, both in the fundamental science arena as well as translating these scientific discoveries into real applications.

Interpretable deep learning approach for oral cancer classification using guided attention inference network.

Significance: Convolutional neural networks (CNNs) show the potential for automated classification of different cancer lesions. However, their lack of interpretability and explainability makes CNNs less than understandable. Furthermore, CNNs may incorrectly concentrate on other areas surrounding the salient object, rather than the network's attention focusing directly on the object to be recognized, as the network has no incentive to focus solely on the correct subjects to be detected.

Compressive Myelopathy Secondary to Skeletal Dysplasia: Spondylometaphyseal Dysplasia, Kozlowski Type.

Transient receptor potential vanilloid 4 channel ( ) gene mutations have been described in skeletal system and peripheral nervous system pathology. The case described here is a 9-year-old male child patient, born to a nonconsanguineous marriage with normal birth history who had difficulty in walking and stiffness of joints for the last 7 years, and progressive weakness of all four limbs and urine incontinence for 1 year following falls. Physical examination showed below-average weight and height and short trunk.

Electric field control of chirality.

Polar textures have attracted substantial attention in recent years as a promising analog to spin-based textures in ferromagnets. Here, using optical second-harmonic generation–based circular dichroism, we demonstrate deterministic and reversible control of chirality over mesoscale regions in ferroelectric vortices using an applied electric field. The microscopic origins of the chirality, the pathway during the switching, and the mechanism for electric field control are described theoretically via phase-field modeling and second-principles simulations, and experimentally by examination of the microscopic response of the vortices under an applied field.

A secondary assessment of sediment trapping effectiveness by vegetated buffers.

Vegetated buffers and filter strips are a widely used Best Management Practice (BMP) for enhancing streamside ecosystem quality and water quality improvement through nonpoint source pollutant removal. Most existing studies are either site-specific, rely on limited data points, or evaluate buffer width and slope as the only design variables for predicting sediment reduction, not considering other parameters such as soil texture, vegetation types, and runoff loads that can significantly influence the buffer efficiency. In this paper, we carry out a meta-analysis of published studies and fit regression models to explore the sediment removal capacity of riparian buffers.

Isolation, characterisation, anticancer and anti-oxidant activities of 2-methoxy mucic acid from : an and studies.

The main objective of the present study is to isolate and characterise the novel bioactive molecule, 2-methoxy mucic acid from Blume under the family. In this study, the 2-methoxy mucic acid ( was isolated for the first time from the methanolic extract of the leaves of . Anticancer activity of 2-methoxy mucic acid () was evaluated against HeLa and MDA-MB-231 cancer cell lines and they displayed promising activity with IC values of 22.

Tunable Nanoscale Evolution and Topological Phase Transitions of a Polar Vortex Supercrystal.

Understanding the phase transitions and domain evolutions of mesoscale topological structures in ferroic materials is critical to realizing their potential applications in next-generation high-performance storage devices. Here, the behaviors of a mesoscale supercrystal are studied with 3D nanoscale periodicity and rotational topology phases in a PbTiO /SrTiO (PTO/STO) superlattice under thermal and electrical stimuli using a combination of phase-field simulations and X-ray diffraction experiments. A phase diagram of temperature versus polar state is constructed, showing the formation of the supercrystal from a mixed vortex and a-twin state and a temperature-dependent erasing process of a supercrystal returning to a classical a-twin structure.

Characterization of Spp. Inciting Vascular Wilt of Tomato and Its Management by a -Based Biocontrol Consortium.

Though the vascular wilt of tomato caused by the species of is globally reported to be a complex disease in certain countries, for example, India, our studies indicated that the disease is caused by either f. spp. (Fol) or (FS) with the Fol being widely prevalent.

Identification of a Novel Series of Potent Organosilicon Mosquito Repellents.

Mosquito control by personal protection is one of the most efficient ways of curtailing deadly diseases such as malaria and dengue with the potential to save millions of lives per year. DEET (,-diethyl-3-methyl benzamide) is currently considered as the gold standard for mosquito repellents, being used for the past several decades. Control by DEET, however, is being threatened by emerging resistance among mosquitoes.

Synergistic Effects of ASBT-2 with Oxyresveratrol Isolated from Coconut Shell Waste.

Value-added phytochemicals from food by-products and waste materials have gained much interest and among them, dietary polyphenolic compounds with potential biological properties extend a promising sustainable approach. Oxyresveratrol (Oxy), a stilbenoid polyphenol, possesses great therapeutic potential, though its pharmacokinetic issues need attention. A good source of oxyresveratrol was found in underutilized coconut shells and the synbiotic applications of the compound in combination with a potential probiotic isolate ASBT-2 was investigated.