Exploring the potential therapeutic benefits of 7-methoxy coumarin for neuropathy pain: an in vivo, in vitro, and in silico approach.

Back Ground: 7-Methoxycoumarin (7-MC) is well recognized for its anti-inflammatory and anti-nociceptive actions. Its capacity to lessen neuropathic pain hasn't been documented yet. Hence the impact of 7-MC on vincristine-induced peripheral neuropathic pain in rodents was investigated.

The Smart Drug Delivery of Rotigotine Using Transdermal Patch for the Successful Management of Parkinson's Disease.

Background: A Non-Ergot Dopamine Agonist (NEDA) rotigotine has been designed as a new transdermal drug delivery system.

Aim: To maintain optimum homogeneity in drug content, the rotigotine transdermal patch was developed utilizing a solvent casting technique.

Methods: The characteristics of a transdermal patch, including patch weight, folding endurance, patch thickness, surface morphology, tensile strength, swelling rate, surface pH, in vitro release studies, water retention rate, uniformity of drug content, and ex-vivo permeation studies, were determined.

Prediction modeling using artificial neural network (ANN) for the performance and emission characteristics of catalytic co-pyrolytic fuel blended with diesel in a CI engine.

In the present research work, artificial neural network (ANN) is used to model the performance and emission parameters in a four-stroke, single-cylinder diesel engine combusting a blended fuel of diesel and catalytic co-pyrolysis oil produced from seeds of Pongamia pinnata, waste LDPE, and calcium oxide catalyst. The optimum yield of oil obtained was 92.5% at 500 °C temperature.

Performance and emission analysis of blends of bio-oil obtained by catalytic pyrolysis of Argemone mexicana seeds with diesel in a CI engine.

Because of their adaptability and user-friendliness, internal combustion engines are widely used for a variety of purposes, including the generation of consistent power as well as transportation. As a result, the question of whether or not these engines can make use of bio-oils is an important one today. Bio-oils derived from biomass pyrolysis differ significantly from those derived from petroleum-based fuels and biodiesel.

Unravelling the Nature of the Intrinsic Complex Structure of Binary-Phase Na-Layered Oxides.

The layered sodium transition metal oxide, NaTMO (TM = transition metal), with a binary or ternary phases has displayed outstanding electrochemical performance as a new class of strategy cathode materials for sodium-ion batteries (SIBs). Herein, an in-depth phase analysis of developed Na TMO cathode materials, Na Ni Fe Mn O with P2- and O3-type phases (NFMO-P2/O3) is offered. Structural visualization on an atomic scale is also provided and the following findings are unveiled: i) the existence of a mixed-phase intergrowth layer distribution and unequal distribution of P2 and O3 phases along two different crystal plane indices and ii) a complete reversible charge/discharge process for the initial two cycles that displays a simple phase transformation, which is unprecedented.

Dual Heteroatom-Doped Carbon Nanofoam-Wrapped Iron Monosulfide Nanoparticles: An Efficient Cathode Catalyst for Li-O Batteries.

Cost-effective dual heteroatom-doped 3D carbon nanofoam-wrapped FeS nanoparticles (NPs), FeS-C, act as efficient bifunctional catalysts for Li-O batteries. This cathode exhibits a maximum deep discharge capacity of 14 777.5 mA h g with a 98.

Zinc-air battery: understanding the structure and morphology changes of graphene-supported CoMn(2)O(4) bifunctional catalysts under practical rechargeable conditions.

Nitrogen-doped/undoped thermally reduced graphene oxide (N-rGO) decorated with CoMn2O4 (CMO) nanoparticles were synthesized using a simple one-step hydrothermal method. The activity and stability of this hybrid catalyst were evaluated by preparing air electrodes with both primary and rechargeable zinc-air batteries that consume ambient air. Further, we investigated the relationship between the physical properties and the electrochemical results for hybrid electrodes at various cycles using X-ray diffraction, scanning electron microscopy, galvanodynamic charge-discharging and electrochemical impedance spectroscopy.