Outcomes for high-risk defining events in follicular lymphoma following frontline immunochemotherapy.

Progression of follicular lymphoma (FL) or transformation (TFL) within 24 months of immunochemotherapy (ICT) represent high-risk defining events (HRDE) with poor overall survival (OS). We examined baseline clinical characteristics, imaging, and outcomes for patients experiencing HRDE with newly diagnosed FL requiring ICT. HRDE groups were: relapse or progression of FL within 24 months (FL24), early TFL (transformation <24 months of ICT), late TFL (transformation >24 months of ICT).

T-cell dysregulation informs radiotherapy-immunotherapy response in B-cell lymphoma: results from a Phase I trial.

Diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) are highly radiosensitive with immune-driven abscopal responses reported. PD-1/PD-L1 inhibitors are relatively ineffective in DLBCL/FL but evidence suggests synergy with radiotherapy (RT), yet no clear biomarkers. This phase I study (NCT03610061) examined safety of escalating RT dose and treated volumes with durvalumab (PD-L1i) in thirty-four adult relapsed/refractory (RR)DLBCL and RRFL and the role of immune-cell subsets on outcomes.

Prognostic Markers within the Tumour Microenvironment in Classical Hodgkin Lymphoma.

Classical Hodgkin lymphoma (cHL) accounts for 0.4% of all new cancer cases globally. Despite high cure rates with standard treatment, approximately 15% of patients still experience relapsed or refractory (RR) disease, and many of these eventually die from lymphoma-related causes.

Quality improvement review of O positive blood in emergency transfusion.

Background: We recently introduced a policy to use O positive red cells in emergency transfusions for males >16 years of age and females >50 years of age. Here, we investigate changes in emergency transfusion practice and rates of red cell alloimmunization with the use of O positive blood for emergency transfusion.

Study Design And Methods: State-wide retrospective review of emergency transfusions between June 2020 and June 2021.

Frailty and chronic kidney disease: A systematic review.

Objective: Frailty is associated with increased vulnerability to poor health. There is growing interest in understanding the association between frailty and chronic kidney disease (CKD). This systematic review explored how frailty is measured in patients with CKD and the association between frailty and adverse outcomes across different stages of renal impairment.