Intraosseous Mucoepidermoid Carcinoma of the Maxilla Mimicking an Odontogenic Lesion.

Mucoepidermoid carcinoma (MEC) is the most common malignant neoplasm of salivary gland origin, accounting for approximately 27% of all salivary gland malignancies. While it frequently involves the parotid gland, intraoral cases show a predilection for the palate. Rarely, MEC can arise within the facial skeleton, where it is the most common salivary gland tumor to occur intraosseously.

Human Dirofilariasis- An Underrecognized Zoonosis.

Dirofilariasis is a rare zoonotic disease caused by the filarial nematode of the genus Dirofilaria. It is an uncommon zoonosis which was previously reported in endemic areas. However, with climate change, it is being reported in non-endemic areas too.

Unifocal Langerhans Cell Histiocytosis.

Langerhans cell histiocytosis is a rare disease which is more common in the childhood. Clinical presentation may vary ranging from single to multiple organ involvement. Skeleton is often involved and in the maxillofacial region, it affects the mandible more than the maxilla.

E-Cadherin is a diagnostic biomarker in the progression of oral epithelial dysplasia to squamous cell carcinoma.

Background: Oral squamous cell carcinoma is a common cancer of head and neck region with poor prognosis and may sometimes show a premalignant stage. Cell-cell adhesion molecules play an important role in the process of malignant transformation. E-cadherin, a cell-to-cell adhesion molecule, plays a crucial role in maintaining cell polarity and adhesion of epithelial cells.

Minichromosome maintenance protein 5 - a promising prognostic marker of oral epithelial dysplasias and oral squamous cell carcinomas.

Background: Early diagnosis is the single most effective means of reducing the mortality rate of oral cancer.

Aim: This study was undertaken to assess the expression of minichromosome maintenance protein 5 (MCM5) in oral epithelial dysplasias and oral squamous cell carcinomas (OSCCs) and to evaluate their possible role as a biomarker for early diagnosis and prognosis of OSCC.

Design: A retrospective cross-sectional study.

Primordial odontogenic tumour: Report of a novel entity - The third case from India.

Primordial odontogenic tumour (POT) is a newly described benign mixed odontogenic neoplasm that has been included in the World Health Organization classification 2017. Only 19 cases that conform to the clinico-pathologic criteria for diagnosis have been reported worldwide. We present the 20 case of POT reported worldwide and is only the third case to be reported from India.

Frameshift mutation in exon 17 of PTCH1 gene in Nevoid basal cell carcinoma syndrome: A case report.

Nevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disorder characterized by a wide range of developmental abnormalities and a predisposition to neoplasms. In majority of the cases, the presence of multiple and recurrent jaw cysts especially during the first two decades of life is one of the first symptoms of this syndrome. We present here a case of 14-year-old female patient who reported with a chief complaint of facial swelling for 3 weeks.

Immunohistochemical analysis of cathepsin-D in benign and malignant salivary gland neoplasms. Evaluation of its role as a prognostic indicator.

Background: Salivary gland tumors are histologically the most heterogeneous group of tumors. Traditional diagnostics and grading of these tumors often fail to provide any insight into patient's clinical course. Cathepsin-D is a lysosomal acid protease secreted in increased levels in several malignancies.

Spindle cell haemangioma - Report of a rare entity.

Spindle cell haemangioma is a rare benign vascular neoplasm. Its occurrence in the oral cavity is uncommon and may be mistaken for other common oral lesions such as mucoceles or fibromas. Microscopically, it has features which are similar to those of other vascular neoplasms and may be a cause for potential mis-diagnosis.

Attitude and perceptions regarding online teaching in dental undergraduate program during COVID-19 pandemic: A mixed method study.

Background: Transformation of education to virtual mode during COVID-19 pandemic was a major challenge for a clinical specialty like dentistry.

Materials And Methods: A sequential explanatory mixed method was adopted with quantitative dominant design. A self-reported questionnaire on attitude and perceptions toward online learning were distributed among dental undergraduate students.

A Rare Case of Intra-Oral Dirofilariasis Manifesting on The Buccal Mucosa.

Dirofilariasis is a rare zoonotic disease endemic in tropical and sub-tropic countries, including India. Caused by the nematode of the genus Dirofilaria, the disease usually affects canines which form the primary hosts. Humans rarely get infected through the bite of potential mosquito vectors.

Nonspecific Cystic Degeneration in Craniofacial Fibrous Dysplasia: A Rare Finding.

Fibrous dysplasia (FD) is a developmental pathology of the bones in which normal bone is replaced by fibrous tissue and immature bone. It can affect single bone (monostotic) or multiple bones (polyostotic), sporadically or in association with McCune-Albright syndrome, Jaffe-Lichtenstein syndrome, or Mazabraud syndrome. When multiple bones in the craniofacial region are affected, the term "craniofacial FD" is used.

Histopathologic evaluation of oral lichen planus and oral lichenoid reaction: A comparative analysis based on basement membrane thickness and the distribution of mast cells.

Background: Lichen planus is a chronic mucocutaneous disease of unknown etiology with well-established clinical and microscopic features. Oral lichenoid reactions are a family of lesions triggered by contact with specific agents such as metallic restorative materials, resins and drugs. Oral lichenoid reactions share clinical and histological features of oral lichen planus (OLP) but has varied management options.

Institutional quarantine centres as a strategy in control of COVID-19 outbreak: An evolving model from Kerala, India.

Background: Institutional quarantine centres were set up in all districts in Kerala as a novel strategy in the fight against novel COVID-19 virus. These were meant for returnees from affected areas, for whom home quarantine was not possible due to lack of facilities. This research aims to evaluate facilities and services of Institutional quarantine centres in Thiruvananthapuram district, Kerala state and to study profile of persons under quarantine in these centres.

Prevalence of odontogenic cysts and its associated factors in South Indian population.

Background: Odontogenic cysts (OCs) constitute a major part of oral pathological lesions, but little is known about their distribution patterns in various populations.

Aims: The aim was to determine the prevalence and factors associated with the cases of histopathologically diagnosed OCs that report to our institution and to analyze the factors associated with the presence of OCs and to study the biologic behavior of different types of cysts.

Materials And Methods: A cross-sectional study was performed on 596 oral and maxillofacial specimens during 2013-2017.

Expression of CK 19 as a biomarker in early detection of oral squamous cell carcinoma.

Background: Increased mortality in oral squamous cell carcinoma (OSCC) had been attributed to delay in diagnosis. Lack of a specific marker to assess the malignant potential of premalignant lesions is thought to be one of the reasons for late detection. Expression of Cytokeratin 19, which is widely used as an odontogenic epithelial marker had been reported in OSCC.

Oral myofibroma presenting as an aggressive gingival lesion.

Myofibromas are benign neoplasms of myofibroblastic origin and rarely encountered in the oral cavity. Myofibroma may frequently grow rapidly leading to suspicion of malignancy. This may lead to a tendency for aggressive management.

Mucoepidermoid carcinoma of retromolar area: an incidental finding.

Salivary gland tumours can arise in any location in the oral cavity but are rather rare in the retromolar region. The majority of the salivary neoplasms arising here are malignant in nature. Mucoepidermoid carcinoma is more commonly seen in the palate.

Dental Care Implications in Coronavirus Disease-19 Scenario: Perspectives.

Aim: The aim of this review is to discuss the implications of COVID-19 on various aspects of dental care.

Background: The COVID-19 pandemic had suspended dental practice globally for over 3 months. While dental practice is being resumed cautiously, standard infection control protocols that were traditionally overlooked are now being strictly implemented.

Primary Intraosseous Adenoid Cystic Carcinoma with Widespread Skeletal Metastases Showing Features of High-Grade Transformation.

Malignant salivary gland carcinomas arising primarily within the jaw bones are extremely rare. The most common salivary malignancy in these locations is mucoepidermoid carcinoma followed by adenoid cystic carcinoma and adenocarcinoma. The clinical picture and imaging studies of these malignancies may be confused with odontogenic lesions which are more common in this location.

An immunohistochemical evaluation of podoplanin expression in oral leukoplakia and oral squamous cell carcinoma to explore its potential to be used as a predictor for malignant transformation.

Background: Oral leukoplakia (OL) is a potentially malignant disorder with increased risk for the development of oral squamous cell carcinoma (OSCC). Many cases of OSCC arise from the malignant transformation of preexisting OL. However, the risk of progression into OSCC and the possible prediction of malignant potential of OL remain inconclusive.

Extranodal diffuse large B cell lymphoma of maxillary sinus presenting as a palatal ulcer.

A multitude of disease processes ranging from periodontitis to malignancies can lead to formation of solitary ulcer on the palate. Hence solitary ulcers of palate can often be a challenging one to diagnose. We report an interesting case of a diffuse large B cell lymphoma of the maxillary sinus which perforated the palatal bone and presented clinically as a palatal ulcer.

Benign osteoblastoma of the palate: a rare clinical presentation.

Osteoblastoma is a rare, benign type of osteoblastic tumor. It constitutes approximately 1% of all primary bone tumors. Osteoblastoma most commonly affects the long bones; it very rarely affects the jaw bones.