Publications by authors named "Rachel M Hollander"
Myxomatous degeneration is a non-inflammatory degenerative process leading to disruption of the fibrosa layer of the valve with acid mucopolysaccharide accumulation. This type of degeneration commonly affects the mitral valve leading to mitral regurgitation; however, few cases have been reported regarding myxomatous degeneration of the aortic valve leading to acute decompensated heart failure. We report a case of myxomatous degeneration of the aortic valve as an etiology of acute decompensated heart failure to highlight the importance of considering myxomatous degeneration as an underlying etiology of symptomatic aortic insufficiency.
View Article and Find Full Text PDFAzithromycin is a broad-spectrum antibiotic of the macrolide class and has multiple effects on the cardiovascular system, including prolonged corrected QT (QTc) interval. However, there is limited literature on the association between azithromycin and bradyarrhythmias. Monitoring the patient via telemetry can detect bradycardia.
View Article and Find Full Text PDFArticle Synopsis
- SCN8A encephalopathy results from gain-of-function mutations in the Nav 1.6 sodium channel, causing early onset seizures, intellectual disability, and developmental delays in infants, with a significant percentage facing treatment-resistant seizures and potential sudden death.
- High doses of phenytoin have shown effectiveness in some patients, prompting research into the mutation’s specific effects and its response to the drug.
- Experimental results indicate that the SCN8A mutation I1327V enhances neuronal excitability and alters sodium channel dynamics, while phenytoin was found to improve activation and inactivation properties of the mutant channels, suggesting a potential treatment pathway.