Publications by authors named "Rachael A Hancox"
After the publication of this work [1] an error was noticed in Fig. 6 (b). In the MCF-7/Vector columns, the same image was used accidentally for the 0 h and 24 h time points.
View Article and Find Full Text PDFIntroduction: Tenascin-C (TNC) is a large extracellular matrix glycoprotein that shows prominent stromal expression in many solid tumours. The profile of isoforms expressed differs between cancers and normal breast, with the two additional domains AD1 and AD2 considered to be tumour associated. The aim of the present study was to investigate expression of AD1 and AD2 in normal, benign and malignant breast tissue to determine their relationship with tumour characteristics and to perform in vitro functional assays to investigate the role of AD1 in tumour cell invasion and growth.
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- The extracellular matrix (ECM) in tumors, particularly in breast cancer, is altered and plays a significant role in tumor cell behavior, with specific focus on the protein tenascin-C (TNC) and its isoforms TNC-16 and TNC-14/16.
- The study used various breast cancer cell lines to analyze how these TNC isoforms affect tumor cell proliferation and invasion, particularly comparing their effects to other TNC isoforms.
- Results indicated that TNC-16 and TNC-14/16 promote breast cancer cell growth and invasive capabilities, likely involving matrix metalloproteinases (MMPs), highlighting a critical role for these specific TNC
WNT5A expression increases during melanoma progression and correlates with outcome.
Clin Cancer Res
September 2008
Purpose: Wnt ligands play a major role in development and are important in cancer. Expression microarray analysis correlates one member of this family, WNT5A, to a subclass of melanomas with increased motility and invasion. There are no large studies of clinical samples primarily addressing the importance of WNT5A in melanoma progression or outcome.
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