DNA-encoded library screening uncovers potent DNMT2 inhibitors targeting a cryptic allosteric binding site.

DNMT2 (TRDMT1) is a human RNA methyltransferase implicated in various disease processes. However, small-molecule targeting of DNMT2 remains challenging due to poor selectivity and low cellular availability of known -adenosylhomocysteine (SAH)-derived ligands. In this study, a DNA-encoded library (DEL) screen identified five non-SAH-like chemotypes that selectively bind DNMT2, including three peptidomimetics.

Beyond Self-Reports: Integrating Cortisol Measurement in Psychotherapy Process Research among Adolescents with Borderline Personality Pathology.

Psychotherapy is the primary treatment for adolescent Borderline Personality Pathology (BPP), yet its mechanisms remain unclear. Given potential self-report biases due to alexithymia and impaired interoception, this study examined cortisol responses as a physiological stress marker alongside session ratings from adolescent BPP patients and their therapists to assess its potential as a complementary measure in psychotherapy process research. N = 56 adolescents (94.

Influence of low and high sulphur marine engine fuels and wet scrubbing on heavy metal emissions from ships.

Emissions from ships significantly contribute to global air pollution, especially in coastal regions. Marine engines emit high levels of particulate matter (PM), which may contain toxic heavy metals depending on the fuel used. Current regulations on fuel sulphur content (FSC) permit the use of heavy fuel oils (HFOs) only with wet sulphur scrubbers, but do not regulate the PM and heavy metal content directly.

Infectious Proctitis Mimicking Advanced Rectal Cancer: A Case Report and Update on the Differential Diagnosis of Rectal Ulcerations.

: Infectious proctitis remains an underrecognized entity, although sexually transmitted diseases, especially bacterial infections, exhibit a marked increase in their incidence. : Here, we report a case of a 44-year-old man who presented to the emergency department with lower abdominal and rectal pain, tenesmus, fever and night sweats for the past 6 days. : The computed tomography initially revealed a high suspicion of metastatic rectal cancer.