Acylcarnitine enrichment as a characteristic of rheumatoid arthritis fibroblast-like synoviocyte metabolic fingerprint.

Objective: In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) alter their metabolism to support their activation. We aimed to analyse the full spectrum of metabolic alterations associated with RA by performing untargeted metabolomics in RA FLS vs. non-inflamed (NI) FLS.

A multicentric study examining a deep-learning-based computer model for classifying bipolar disorder using retinal vascular images.

Objectives: Due to easy accessibility, the retina is considered a window to the brain. Recent studies have reported retinal vascular abnormalities in bipolar disorder. Deep learning analysis, an advanced computational approach, has been implemented in medicine for diagnosis using retinal vascular images.

Deformation, Rupture, and Morphology Hysteresis of Copolymer Nanovesicles in Uniform Shear Flow.

Copolymer nanovesicles are used extensively in chemical processes and biomedical applications in which they are subjected to dynamic flow environments. Flow-induced vesicle deformation, fragmentation, and reorganization modify the energetic (e.g.

Design, Synthesis and In Vitro Evaluation of Levodopa Stearic Acid Hydrazide Conjugate for the Management of Parkinson's DiseaseNovel Conjugate for Parkinson's Disease.

Parkinson's disease is the highest prevalent neurodegenerative disease in elderly individuals after Alzheimer's disease. The pathological identification for Parkinson's disease is loss of dopaminergic neurons in substantia nigra region of the brain that in turn leads to dopamine deficiency that affects the body's normal physiological and neurological disorder. The important drawback in the modality of treatment is levodopa is only supplying depleted dopamine in the brain, it does not affect neurodegeneration.