Genomic epidemiology of dengue virus 2 and 3 reveals repeated introductions and exportations of several lineages in Colombia.

Dengue fever, a major mosquito-borne viral disease, is transmitted by mosquitoes and poses a significant global health burden. Despite extensive research, the spatiotemporal dynamics of dengue virus (DENV) lineages in Colombia remain understudied. Here we analyze 11,443 complete genome sequences from Colombia and the Americas to map the genomic epidemiology of DENV-2 and DENV-3.

Myocardial Strain Measurements Obtained with Fast-Strain-Encoded Cardiac Magnetic Resonance for the Risk Prediction and Early Detection of Chemotherapy-Related Cardiotoxicity Compared to Left Ventricular Ejection Fraction.

Breast and hematological cancer treatments, especially with anthracyclines, have been shown to be associated with an increased risk of cardiotoxicity (CTX). An accurate prediction of cardiotoxicity risk and early detection of myocardial injury may allow for effective cardioprotection to be instituted and tailored to reverse cardiac dysfunction and prevent the discontinuation of essential cancer treatments. The PRoactive Evaluation of Function to Evade Cardio Toxicity (PREFECT) study sought to evaluate the ability of fast-strain-encoded (F-SENC) cardiac magnetic resonance imaging (CMR) and 2D echocardiography (2D Echo) to stratify patients at risk of CTX prior to initiating cancer treatment, detect early signs of cardiac dysfunction, including subclinical CTX (sub-CTX) and CTX, and monitor for recovery (REC) during cardioprotective therapy.

Feeding the cosmos: tackling personalized space nutrition and the leaky gut challenge.

Long-duration space missions pose serious challenges to astronaut nutrition and health due to the altered environment of Low Earth Orbit (LEO). This study examines the nutritional composition of crops grown in space, identifying deficiencies in key nutrients such as calcium and magnesium, along with variable antioxidant profiles. These imbalances may impact astronaut physiology, particularly bone health and immune function, and are potentially linked to altered gene expression pathways in microgravity.

Disparities in Breast Cancer-related Lymphedema: A Systematic Review of Inequities and Barriers in Care.

Background: Breast cancer-related lymphedema (BCRL) is a chronic condition secondary to multimodal cancer treatment. This systematic review summarized the evidence for disparities and barriers surrounding BCRL care, particularly in diagnosis, education, and accessibility to treatment.

Methods: A search of PubMed/MEDLINE, Embase, Scopus, and Web of Science following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was conducted from January 1, 1990, through October 3, 2024.

Functions of Endogenously Produced and Exogenously Applied Melatonin in Higher Plants.

The role of melatonin (MEL) in plants has gained significant relevance due to its involvement in a wide range of physiological functions, particularly in response mechanisms to both abiotic and biotic stresses. Recent progress highlights the significance of the biosynthetic pathway of MEL in plants, which surpasses that of animals. The discovery of specific plant MEL receptors has revealed new signaling mechanisms.