Estimating the associations between women's maltreatment in childhood and inflammatory biomarker levels prior to and during pregnancy.

Background: Maternal childhood maltreatment has been associated with higher risk of adverse neurodevelopment in offspring. Chronic systemic inflammation has been associated with childhood maltreatment and has been identified as a gestational risk factor for adverse neurodevelopment in offspring. Thus, inflammation may be a mechanism by which maternal exposure to maltreatment affects offspring neurodevelopment.

Utility of Breath-Holding Time in Monitoring Acute Neuromuscular Respiratory Failure in Bulbar-Onset Myasthenia Gravis: A Case Report.

We report the management of a 64-year-old male with newly diagnosed bulbar-onset myasthenia gravis (MG) who was hospitalized with acute neuromuscular respiratory insufficiency. This case highlights the challenges in monitoring respiratory function in MG patients, especially in the presence of bulbar and nuchal weakness, and emphasizes the potential utility of single breath-hold time (SBHT) over forced vital capacity (FVC) as a reliable bedside monitoring tool. Despite initial stabilization with intravenous immunoglobulin (IVIG), the patient deteriorated, requiring escalation to the intensive care unit (ICU), and the clinical worsening corresponded with the SBHT rather than with FVC.

Developing Biocompatible Chitosan-Stabilized Gold Nanoparticles with Anticancer and Antimicrobial Properties: A Computational and Experimental Approach.

The present study reports an eco-friendly route for the synthesis of chitosan-stabilized gold nanoparticles (Cs@AuNPs) using leaf extract and their dual anticancer and antimicrobial activities. The nanoparticles were comprehensively characterized by ultraviolet-visible (UV-vis) spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and ζ-potential analysis. Cs@AuNPs exhibited a strong surface plasmon resonance peak at 550 nm, face-centered cubic crystallinity with a predominant (111) plane, spherical morphology, particle size ranging from 5-30 nm, and a positive surface charge.

Systemic AA Amyloidosis Secondary to Chronic Bronchiectasis and Primary Immunodeficiency: A Case Report.

A 37-year-old ex-teacher, having suffered severe bronchiectasis for over a decade and not diagnosed as having primary specific antibody deficiency, later developed systemic AA amyloidosis and end-stage renal disease. Persistent respiratory symptoms developed at age 26, and subsequent investigations revealed cylindrical bronchiectasis and impaired specific antibody responses to and . Lack of compliance with the treatment and follow-up despite continuous specialist treatment led to a gradual decline in lung function and frequent and -induced infections.

Cohort profile of the ICMR-Stillbirth Pooled India Cohort (ICMR-SPIC): estimating prevalence, analysing risk factors and developing prediction models for stillbirths in India.

Purpose: Stillbirth is a significant public health problem in India, yet comprehensive epidemiological data on its prevalence and risk factors are lacking. The objectives of this research were to develop a dataset pooled from 10 well-characterised pregnancy cohorts across urban and rural India to estimate the prevalence of stillbirths, identify and quantify risk factors and develop a predictive risk stratification model for evidence-based clinical decision-making in high-risk pregnancies.

Participants: Pregnant women were enrolled during the antenatal period in 10 existing cohorts across India.