A comprehensive experimental study on the mechanisms of waterflood inefficiency in a Morrowan sandstone reservoir.

An indispensable factor in developing improved enhanced oil recovery (EOR) is the in-depth insight into the fractional flow mechanistic effects of waterflood performance, especially for an inefficient waterflood operated field. In this study, the inefficiency of waterflood on the Farnsworth Field Unit (FWU) is investigated. The field is divided into two halves (East and West) of the same reservoir with similar geological characteristics.

Development of novel benzamide class I selective lysine deacetylase inhibitors as potent anticancer agents.

Small molecule inhibitors of lysine deacetylases (KDACs), exemplified by histone deacetylases (HDACs), exhibit significant promise as cancer therapeutics. Using a modular combinatorial chemistry approach, a novel class of KDAC inhibitors (KDACi) containing the aminophenyl-benzamide headgroup have been developed, which incorporate a vinyl group within the linker region for active site stabilisation and a trifluoromethyl moiety within the capping group to exploit enzyme surface topology. Consequently, a class I selective KDACi () with a preference towards HDAC1 over other class I KDACs was identified.

Outpatient surgical management of head and neck keratinocyte cancers in a regional centre: an updated analysis of costs and outcomes.

Background: Australia has the highest global incidence of keratinocyte cancer. Surgically managing keratinocyte cancers in regional Australia presents geographic and economic challenges, which necessitate cost-effective resource allocation. Previous work has outlined the cost benefit for outpatient day surgical excision of head and neck skin lesions that can be closed primarily.

Detection of sedentary time and bouts using consumer-grade wrist-worn devices: a hidden semi-Markov model.

Background: Wrist-worn data from commercially available devices has potential to characterize sedentary time for research and for clinical and public health applications. We propose a model that utilizes heart rate in addition to step count data to estimate the proportion of time spent being sedentary and the usual length of sedentary bouts.

Methods: We developed and trained two Hidden semi-Markov models, STEPHEN (STEP and Heart ENcoder) and STEPCODE (STEP enCODEr; a steps-only based model) using consumer-grade Fitbit device data from participants under free living conditions, and validated model performance using two external datasets.

Barriers and facilitators of adherence to low-dose aspirin during pregnancy: A co-produced systematic review and COM-B framework synthesis of qualitative evidence.

Introduction: Women at increased risk of developing pre-eclampsia are advised to take a daily low-dose of aspirin from 12 weeks of pregnancy to reduce their risks. Despite the well-established prophylactic effect of aspirin, adherence to this therapy is low. This systematic review aimed to summarise evidence on the barriers and facilitators of adherence to low-dose aspirin to inform intervention development to support decision making and persistence with aspirin use for pre-eclampsia prevention.