Efficacy of Mineral Trioxide Aggregate Versus Biodentine as a Direct Pulp Capping Material in Carious Human Mature Permanent Teeth: A Systematic Review.

The present systematic review and meta-analysis aimed to evaluate and compare the clinical efficacy of Mineral Trioxide Aggregate (MTA) and Biodentine (BD) as direct pulp capping materials in cariously exposed mature permanent teeth, focusing on outcomes such as pulp vitality preservation, dentin bridge formation, and complication rates, including tooth discoloration. A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, and other dental databases following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The review protocol was registered in PROSPERO (CRD42023463513).

Comparison of Revascularization and Apexification Using Mineral Trioxide Aggregate in Young Human Immature Nonvital Teeth: A Systematic Review and Meta-Analysis.

The management of immature nonvital permanent teeth in young patients remains a clinical challenge due to open apices and incomplete root development. Revascularization (RET) and apexification using mineral trioxide aggregate (MTA) are the two most widely used treatment modalities, but their comparative effectiveness remains debated. The present systematic review and meta-analysis compared RET and MTA apexification for treating immature nonvital teeth in patients aged 6-18 years.

Beyond Pairwise Interactions: How Interfacial Polarization Modulates Water Flow in Graphene Nanochannels.

Although incorporating many-body polarization effects is essential for accurately modeling water transport under nanoconfinement, the use of conventional pairwise additive force fields fails to account for polarization-induced charge redistribution at the interface. Using Grand Canonical Molecular Dynamics (GCMD) simulations, we demonstrate that explicitly incorporating many-body polarization effects to model graphene-water interactions as well as graphene flexibility is essential for accurately predicting water interfacial structure and dynamics under nanoconfinement. For narrow channels of 8 Å spacing, graphene polarization is shown to disrupt the confinement-induced ordering of water predicted using Lennard-Jones-based nonpolarizable force fields, resulting in (i) increased out-of-plane orientations of the water molecules, (ii) weakening of hydrogen bonding and hindering of water crystallization, and (iii) faster force decorrelation, resulting in lower interfacial friction.

Formulation of Polarizable Force Fields to Model Simple Ionic Liquid/Graphite Interfaces.

Force fields that are specifically parametrized for performing molecular dynamics simulations of liquid/solid interfaces are in high demand. Such interfaces are broadly present in nature and applied in, for example, batteries, membranes, or catalysts, and therefore, an accurate modeling is required, including the explicit treatment of electronic polarization effects. In molecular dynamics simulations, the liquid/solid interactions are most often modeled by combining existing force fields for both phases using mixing rules.

Predictors of Type 3 Diabetes Mellitus among Elderly Living with and without Type 2 Diabetes Mellitus: A Cross-sectional Study in the Urban Area of West Bengal.

Introduction: In view of the latest evidence, dementia is also regarded as type 3 diabetes mellitus (T3DM) due to the important role of brain insulin resistance in its pathogenesis. Our study objectives were to find out the proportion and predictors of mild cognitive impairment (MCI) and T3DM (dementia) among the elderly people living with and without type 2 diabetes mellitus (T2DM) attending a medical college outpatient department (OPD).

Materials And Methods: A cross-sectional study was conducted comparing elderly patients from diabetes clinic OPD and general medicine OPD of a medical college in West Bengal.