Routine cell-free DNA prenatal screening identifies pregnancies at high risk for cystic fibrosis that may benefit from fetal therapy.

Recent improvements in cell-free DNA technology have enabled non-invasive prenatal testing (NIPT) to screen for fetal single-gene autosomal recessive conditions from maternal blood as early as the first trimester. This technique can determine the fetal risk for cystic fibrosis (CF) with a single blood sample from a pregnant person without the need for a partner sample, which is required for traditional carrier screening. A retrospective review of 100,106 consecutive general-risk pregnant patients who underwent CF carrier screening was completed.

Prospective Comparison of Ultra-high-resolution Photon-counting-detector CT Coronary Angiography versus Conventional CT.

Objectives: Determine differences in quantitative stenosis severity measurements for ultra-high-resolution (UHR) photon-counting-detector (PCD) coronary CT angiography (cCTA) relative to energy-integrating-detector (EID) cCTA in a large patient cohort.

Methods: Adult participants seen between November 2022 and March 2023 underwent a clinical dual-source EID-CT cCTA and a research dual-source PCD-CT cCTA on the same day. Percent diameter stenosis (PDS) was measured, and stenosis severity was assigned based on the PDS of the most severe lesion per patient to determine a coronary-artery-disease reporting and data system (CAD-RADS) score.

A graph theory-based algorithm for the reduction of atmospheric chemical mechanisms.

The atmospheric chemistry of volatile organic compounds (VOC) has a major influence on atmospheric pollutants and particle formation. Accurate modeling of this chemistry is essential for air quality models. Complete representations of VOC oxidation chemistry are far too large for spatiotemporal simulations of the atmosphere, necessitating reduced mechanisms.

A Rare Case of Metastatic Pulmonary Sarcomatoid Carcinoma.

Pulmonary sarcomatoid carcinoma (PSC) is a rare, aggressive cancer with early metastasis and poor prognosis. Chest X-ray and computed tomography (CT) are common modalities used to detect malignancy, and the diagnosis is confirmed with tissue biopsy. There are currently no guidelines for therapy when treating this condition as it often displays resistance to typical first-line chemotherapy agents.

Delivering a national accelerated HPB cancer management strategy: The pancreatic and hepatocellular cancer pathway improvement project (PHCC-PIP).

Introduction: Diagnostic delays impact pancreatic cancer (PC) and hepatocellular carcinoma (HCC) patients. The Pathway improvement project (PIP) aimed to address this, centralizing oversight of patient's staging pathways across Scotland, thereby streamlining diagnosis to definitive treatment and improving communication.

Methods: A National cancer care team (CCT) received alerts from radiology departments for scans suspicious of PC or HCC.