Safety, Pharmacokinetics, and Acceptability of a Tenofovir Rectal Microbicide Douche Among Young Men Who Have Sex with Men: The DREAM ATN Study (ATN 163).

Background: Young men who have sex with men (YMSM) are disproportionately affected by HIV, yet use of oral pre-exposure prophylaxis (PrEP) remains suboptimal. This study evaluated the safety, pharmacokinetics (PK), pharmacodynamics (PD), and acceptability of a novel tenofovir (TFV) rectal microbicide douche for HIV prevention.

Methods: Eight HIV-negative YMSM (ages 18-24) participated in a single-dose, open-label trial.

Assessing the Acceptability of a Tenofovir-Based Rectal Microbicide Douche among Young Men who Have Sex with Men: Results from ATN-DREAM (ATN 163).

Young men who have sex with men (YMSM) remain disproportionately affected by HIV, yet adherence to daily oral pre-exposure prophylaxis (PrEP) remains suboptimal. Rectal microbicides formulated as douches offer a behaviorally congruent alternative by leveraging existing douching practices. This study assessed the acceptability of a tenofovir-based rectal microbicide douche among YMSM.

Being Out: Impact of Disclosure on Sexual and Reproductive Healthcare Receipt in a Sample of Sexual Minority Women and Gender Diverse Youth.

Purpose: Sexual minority women and gender diverse youth in the United States experience disparities in sexual and reproductive health. We evaluated whether sexual partner type, identity, and attraction were associated with healthcare disclosure, and whether healthcare disclosure was associated with sexual and reproductive healthcare receipt in a sample of sexual minority and gender diverse youth aged 18-24 years assigned female at birth.

Methods: 103 youth assigned female at birth completed a behavioral health survey.