Arthroscopic Collagenous Matrix Therapy for Osteochondral Lesions of the Talus.

Osteochondral lesions of the talus frequently are seen in injuries, typically caused by trauma or repetitive stress, which affect both the cartilage and the underlying bone of the ankle joint. If left untreated, these lesions can result in chronic pain, joint instability, and impaired function. Treatment options traditionally range from conservative approaches to surgical procedures, such as microfracture, osteochondral autografts, and allografts.

Ensuring Quality and Interpretability of Progression Free Survival and Overall Survival in Oncology Clinical Trials.

Time-to-event endpoints, such as progression free survival (PFS) and overall survival (OS), are critical in assessing therapeutic efficacy in oncology drug development. However, their quality and interpretability are frequently challenged by a range of factors, from protocol design and intercurrent events (ICE) to inconsistent data collection and missing follow-up data. These methodological and operational complexities can obscure the true treatment effect.

Fighting tuberculosis hand in hand: A call to engage communities affected by TB as essential partners in research.

Tuberculosis (TB) is an infectious disease closely intertwined with stigma, discrimination, and the social determinants of health. Communities of people affected by TB are experts in their care pathways, but the TB field continues to fall short of meaningfully engaging communities in TB research. This is a missed opportunity to improve the quality, relevance, person-centeredness, positive impact, and sustainability of TB research outputs.

Clinical Characteristics and Outcomes of Children with Unilateral Multicystic Dysplastic Kidney: A Cohort Study.

Objectives: To study the clinical profile and outcomes of children with unilateral multicystic dysplastic kidney (MCDK).

Methods: We assessed the clinical features and extrarenal manifestations in children with unilateral MCDK. These children were followed up to ascertain involution, compensatory hypertrophy and progression of chronic kidney disease (CKD) stage.

Scapular swelling: "subcutaneous cysticercosis unveiled"-a case report.

Background: Cysticercosis, a parasitic infection caused by the larval stages of the pork tapeworm, Taenia solium, predominantly affects cerebral and ocular tissues. The subcutaneous manifestation of this disease is a relatively uncommon clinical occurrence. Previously very few or no cases of cysticercosis presenting as subcutaneous solitary painful swelling have been reported in the literature.