The utility of monitoring end-tidal carbon dioxide in emergency department to predict inhospital mortality of patients presenting with nontraumatic shock: A prospective observational study.

Objectives: We aimed to identify the ability of end-tidal carbon dioxide (EtCO2) to predict inhospital mortality of patients presenting to the emergency department (ED) with nontraumatic circulatory shock. We also attempted to assess the correlation between EtCO2 and other traditional vital signs and laboratory parameters in this patient population at different time points during their resuscitation.

Methods: This was a single-center prospective observational study conducted among patients with nontraumatic circulatory shock who presented to the ED of a tertiary care teaching institute in India.

Optimizing pain relief in clavicle fractures: A case series on ultrasound guided hematoma block.

Ultrasound-guided hematoma block (USHB) has emerged as a promising, minimally invasive technique for providing targeted analgesia in fractures. The information on the safety and efficacy of hematoma blocks in clavicle fractures is limited in the literature. This case series explores the use of ultrasound-guided hematoma blocks for pain management in adult patients presenting to the Emergency department of a level 1 trauma center situated in a Tier 1 city in the northern part of India with clavicle fractures.

An expeditious synthesis of novel DNA nucleobase mimics of (+)-anisomycin.

A glycal based expeditious synthesis of novel nucleoside analogues of (+)-anisomycin is reported. Readily available tri-O-benzyl-D-glucal was converted to a partially protected trihydroxypyrrolidine that is used as a common scaffold for the introduction of various nucleobases at the primary hydroxyl centre. Nucleoside analogues possessing all four DNA bases have been synthesized.