Bioassay-guided isolation of terpenoids from the soft coral and assessment of their antidiabetic and cytotoxic activities.

This study represents the first report on the secondary metabolites from the soft coral . Nine terpenoids (1-9) were isolated by antidiabetic-guided isolation, including a new xeniaphyllane-type diterpenoid (Sclerohumin O, 1) and a new norcaryophyllene-type sesquiterpenoid (Norsclerohumin P, 6). These compounds feature a distinctive 4/9-fused ring system, which was the first isolated in the genus.

Isolation of phytochemicals and exploration the mechanism of Dolichandrone spathacea in the treatment of chronic bronchitis by integrating network pharmacology, molecular docking, and experimental validation.

Background: Dolichandrone spathacea (D. spathacea) is a traditional medicine used to treat chronic bronchitis (CB) in Vietnam and India. However, phytochemicals and potential mechanisms of this species against CB have not been fully illuminated.

Anti-inflammatory glycosides from Gomphandra mollis Merr.: Structural elucidation and mechanistic insights.

Eight previously unreported glycosides, designated gomphandranosides I-VIII, along with nine known compounds, were isolated from the roots of Gomphandra mollis Merr. Their structures were elucidated through comprehensive spectroscopic analyses, including NMR, HR-ESI-MS, CD, DP4+ probability, and ECD calculations. The anti-inflammatory activities of the isolated compounds were assessed using nitric oxide inhibition assays in LPS-stimulated RAW264.

Isolation and purification of sinensetin, and in silico screening of phytochemicals from (Blume) Miq. for anti-breast cancer activity.

(Blume) Miq. (), a traditional herbal medicine, exhibits a wide range of biological activities but its anti-breast cancer effect is not fully established. In this study, sinensetin was isolated and purified through a multistep process, beginning with liquid-liquid partitioning using dichloromethane, followed by classic column chromatography using gradient elution.

Cytotoxicity-guided isolation of elatostemanosides I-VI from W. T. Wang and their cytotoxic activities.

W. T. Wang, a medicinal plant traditionally utilized in herbal remedies, was explored for its cytotoxic properties.

Activation of the Trichodimerol Pathway through Deletion of in Marine YAP001.

Fungal secondary metabolites (SMs) are complex organic compounds comprising a variety of biological activities that are essential in medicine. These natural products can be found in various environments, with studies demonstrating the importance of studying marine-sourced fungi due to the increased potency of the compounds they produce. In this study, we sourced a YAP001 strain isolated from and explored an avenue for the upregulation of its SMs by combining the one-strain-many-compounds (OSMAC) strategy with genetic manipulation of negative global regulator of secondary metabolism, .

Anti-inflammatory and Hepatoprotective Iridoid Glycosides from the Roots of .

Ten previously undescribed iridoid glycosides (-), including monoiridoids, hybrid iridoid-alkaloids, bis-iridoids, noriridoid-iridoid dimers, and tetramers, were isolated from the roots of Merr. Structural elucidation revealed unique sugar chains not previously observed for iridoids and complex tetrameric configurations that are rare in nature. Compounds , , and demonstrated significant anti-inflammatory effects, with IC values ranging from 6.

New Hydrogenated Phenanthrene Glycosides from the Edible Vegetable W.T.Wang with DPP-IV Inhibitory and Hepatoprotective Activity.

Based on molecular networking-guided isolation, 15 previously undescribed hydrogenated phenanthrene glycosides, including eight hexahydro-phenanthrenone glycosides, four tetrahydro-phenanthrenone glycosides, one dihydro-phenanthrenol glycoside, two dimers, and two known dihydrophenanthrene glycosides, were isolated from W.T.Wang, a popular regional edible vegetable at the northwest region of Vietnam.

Discovery of penicillic acid as a chemical probe against tau aggregation in Alzheimer's disease.

Alzheimer's Disease (AD) is a neurodegenerative disorder proven to be caused by the aggregation of protein tau into fibrils, resulting in neuronal death. The irreparable neuronal damage leads to irreversible symptoms with no cure; therefore, disaggregation of these tau fibrils could be targeted as a therapeutic approach to AD. Here we have developed a fungal natural product library to screen for secondary metabolites that have bioactive potential towards AD tau.

Xanthine oxidase inhibition study of isolated secondary metabolites from (Bignoniaceae): and approach.

Xanthine oxidase (XO) has been widely recognized as a pivotal enzyme in developing hyperuricemia, primarily contributing to the excessive production of uric acid during purine metabolism in the liver. One of the standard treatment approaches involves reducing uric acid levels by inhibiting XO activity. In this study, the leaf extract of , traditionally used in folk medicine, was found to inhibit XO activity in the ethyl acetate and butanol fractions at a concentration of 100 µg/mL, their values were 78.