Vaccination, infection, and hybrid immunity: determinants of SARS-CoV-2 IgG antibody levels and protection in Quzhou, China.

Objectives: To investigate the factors influencing SARS-CoV-2 IgG antibody levels and protection in a population that has experienced both vaccination and COVID-19 infections, predominantly caused by the Omicron BA.5.2 and BF.

Seroepidemiological survey of the population 10 years after the implementation of the varicella vaccine 2-dose immunization strategy.

Despite the implementation of a two-dose varicella vaccine (VarV) immunization strategy for over a decade in Quzhou, China, outbreaks of varicella continue to be reported in school settings with high vaccination coverage. This cross-sectional study surveyed healthy individuals aged 3 to 20 years across six districts and counties in Quzhou, China. Serum samples were collected to detect varicella-zoster virus (VZV) IgG antibodies and to evaluate the effectiveness of the two-dose VarV immunization strategy.

Analysis on willingness and its influencing factors of influenza vaccination among HCWs in Quzhou in 2022-2023 influenza season.

The aim of this study was to ascertain the current status of healthcare workers' (HCWs) willingness to receive the influenza vaccination and to identify the influencing factors in Quzhou. A self-administered questionnaire was used to investigate the cognition and vaccination intention of in-service HCWs in 10 medical and health institutions in Quzhou from July to September in 2022, and the influencing factors of vaccination intention were analyzed by Logistic regression. A total of 228 questionnaires were returned, with the effective rate of 95.

Epidemiological characteristics and prediction model construction of hand, foot and mouth disease in Quzhou City, China, 2005-2023.

Background: HFMD is a common infectious disease that is prevalent worldwide. In many provinces in China, there have been outbreaks and epidemics of whooping cough, posing a threat to public health.

Purpose: It is crucial to grasp the epidemiological characteristics of HFMD in Quzhou and establish a prediction model for HFMD to lay the foundation for early warning of HFMD.

Survey of Hepatitis B Vaccination Coverage and Surface Antibody-Positive Rates in People Aged 1-59 Years in 2006 and 2024.

Background: Implementing hepatitis B vaccination is an important strategy to reduce hepatitis B virus infection and disease burden. Suboptimal adult hepatitis B vaccination coverage limits the further reduction of hepatitis B virus infection.

Methods: A multistage stratified random sampling method was adopted to survey the permanent population aged 1-59 in 2006 and 2024.

A case of congenital rubella syndrome and epidemiology of related cases in China, 2014-2023.

Rubella is a major cause of congenital defects, and the presence of rubella infection in a pregnant woman may lead to fetal death or congenital defects known as congenital rubella syndrome(CRS). Since China has not yet established a national CRS surveillance system, the true incidence cannot be determined. To understand the disease burden and epidemiological characteristics of CRS cases in China, the article reports the first case of CRS in Quzhou, China, and conducts a retrospective analysis of related cases that have been reported in China over the past decade.

Effectiveness of COVID-19 vaccines against SARS-CoV-2 Omicron variants during two outbreaks from March to May 2022 in Quzhou, China.

Limited data are available on the effectiveness of COVID-19 vaccines used in China in real-world outbreaks - especially against Omicron variants in vaccinated individuals. Two outbreaks of SARS-CoV-2 Omicron variants - the first involving the sub-lineage BA.2 and the second the BA.

Assessment of mumps-containing vaccine effectiveness by dose during 2006 to 2020 in Quzhou, China.

Mumps cases were reported frequently when a routine dose measles-mumps-rubella(MMR) achieved high coverage in Quzhou. The supplementary immunization activities (SIA) using measles mumps (MM) was conducted to control mumps outbreaks. The effectiveness of one and two doses of mumps-containing vaccine (MuCV) was assessed using surveillance data in this study.

Introduction of Two-Dose Mumps-Containing Vaccine into Routine Immunization Schedule in Quzhou, China, Using Cox-Proportional Hazard Model.

Mumps is a vaccine-preventable disease caused by the mumps virus, but the incidence of mumps has increased among the children who were vaccinated with one-dose measles-mumps-rubella (MMR) in recent years. In this study, we analyzed the influence of different doses of mumps-containing vaccine (MuCV) against mumps using Cox-proportional hazard model. We collected 909 mumps cases of children who were born from 2006 to 2010 and vaccinated with different doses of MuCV in Quzhou during 2006-2018, which were all clinically diagnosed.

Assessing the Changes of Mumps Characteristics with Different Vaccination Strategies Using Surveillance Data: Importance to Introduce the 2-Dose Schedule in Quzhou of China.

Background: From 2005 to 2016, the prevention and control of mumps in China have undergone three stages of transition. These include the use of MuCV as a self-supported vaccine, the introduction of one-dose MMR to the Expanded Program on Immunization (EPI), and the administration of two-dose MuCV following supplementary immunization activities (SIAs) using MM. Here, using surveillance data, we assessed the epidemiology of mumps during the three stages.