ZnO and ZnS Hybrid Film Enhances the Bone Regeneration Performance of Zinc-Based Implants.

Zinc-based biodegradable metal materials have garnered significant attention in recent years due to their favorable mechanical properties, biodegradability, and biocompatibility. Nonetheless, the clinical application of degradable metallic zinc is largely hindered by the uncontrolled release of Zn from the substrate. Herein, a hybrid zinc oxide-zinc sulfide (Zn@ZOS) film was constructed on Zn substrates using the hydrothermal method to slow down the release rate of Zn.

Genetic parameters and genomic prediction of egg production traits in ducks.

Egg production traits are critical in duck breeding. Although genomic selection (GS) has been widely applied in livestock breeding, limited research has focused on predicting duck egg production traits, particularly across different physiological stages. In this study, we systematically explored the genetic parameters of egg production traits and evaluated the performance of GS in a commercial Pekin duck population.

Nuclear binding SET domain 1 alleviates cartilage ferroptosis in knee osteoarthritis by upregulating the krüppel-like factor 9/autophagy-related 14 pathway via H3K36me2 modification.

Knee osteoarthritis (KOA) is a progressive disease featured by cartilage damage. This study attempts to explore the role of nuclear binding SET domain 1 (NSD1) in KOA cartilage ferroptosis, thereby finding a new target for KOA treatment. Pathological changes, cartilage damage, and inflammatory cytokine levels in the established KOA mouse model were assessed.

Optimizing genomic selection strategies for carcass traits in commercial purebred ducks.

Carcass traits are crucial for the meat duck industry, but their measurement in live animals poses challenges, limiting the effectiveness of traditional breeding methods. Genomic selection (GS) is a powerful approach in animal breeding that enhances selection efficiency and reduces costs. However, research on effective genomic selection strategies for improving carcass traits in poultry, particularly commercial purebred ducks, has been scarce.

Utilizing plasma biochemical indicators to improve prediction of economic traits in crossbred duck population.

Plasma biochemical indicators are commonly considered as direct indicators of metabolism and health in both animals and humans. However, genomic predictions for biochemical traits and their downstream utility in predicting economic traits remain unclear. This study explores the genetic parameters of 18 plasma biochemical indicators in a population of 1,059 ducks and evaluates their potential to enhance genomic predictions for 53 economic traits.

Hsa_circ_0001017 promotes cell proliferation, migration and invasion in osteosarcoma by sponging miR-145-5p.

Background: Circular RNAs (circRNAs) have displayed important roles in the development and progression of various cancers. However, the functions of the majority of circRNAs in osteosarcoma (OS) remain unknown.

Methods: Circular RNA microarray analysis was performed in three OS cell lines (Saos-2, U2OS and MG63) and normal vascular endothelial cells.

lncRNA-NEF is downregulated in osteosarcoma and inhibits cancer cell migration and invasion by downregulating miRNA-21.

Long non-coding RNA (lncRNA)-NEF inhibits cancer metastasis in hepatocellular carcinoma; however, its role in other malignancies is unknown. The present study revealed that plasma lncRNA-NEF was downregulated, while miRNA-21 was upregulated in patients with osteosarcoma compared with healthy controls. Plasma lncRNA-NEF and miRNA-21 were negatively correlated in patients with osteosarcoma and healthy controls.

Influence of vertebral column distraction on spinal cord volume: an experimental study in a goat model.

Introduction: Spinal cord injury may be related to excessive distraction of the spinal cord during surgical correction of spinal deformities by vertebral column resection. This study aimed to investigate how vertebral column distraction influences spinal cord volume to establish the safe range in a goat model.

Materials And Methods: A vertebral column resection was performed on the tenth thoracic vertebra of 11 goats.

Relationship between Spinal Cord Volume and Spinal Cord Injury due to Spinal Shortening.

Vertebral column resection is associated with a risk of spinal cord injury. In the present study, using a goat model, we aimed to investigate the relationship between changes in spinal cord volume and spinal cord injury due to spinal shortening, and to quantify the spinal cord volume per 1-mm height in order to clarify a safe limit for shortening. Vertebral column resection was performed at T10 in 10 goats.