Publications by authors named "Qian-Er Wen"

This manuscript used network pharmacology and experimental verification to analyze the anti-hepatocarcinoma mechanism of action of bezoars in traditional Chinese medicine (TCM), discovering that it can affect the immune cells within the tumor microenvironment and related pathways to produce inhibitory effects in liver cancer. In TCM, bezoars have a unique therapeutic advantage in the prevention and treatment of tumors. They play an anti-tumorigenic role by regulating the immune microenvironment through multi-component, multi-target and multi-pathway mechanisms.

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Article Synopsis
  • Breast cancer is a prevalent and increasingly common malignant tumor in women, with triple-negative breast cancer (TNBC) being a particularly aggressive subtype that poses significant treatment challenges.
  • TNBC lacks key hormone receptors, leading to higher rates of metastasis and recurrence, and historically has been primarily treated with chemotherapy.
  • Recent advancements in immunotherapy have introduced new treatment options for TNBC, including immune checkpoint inhibitors and tumor vaccines, offering fresh hope in managing this difficult-to-treat cancer.
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A total of 18% of global breast cancer (BC) deaths are attributed to BC in China, making it one of the five most common cancers there. There has been a steady rise in BC morbidity and mortality in women in the last few years and it is now a leading cancer among Chinese women. Conventional treatments for BC are currently effective but have several limitations and disadvantages, and Traditional Chinese medicine (TCM) plays a vital role in the overall process of cancer prevention and therapy.

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