Multi-task learning for classification and prediction of adolescent idiopathic scoliosis based on fringe-projection three-dimensional imaging.

Purpose: This study aims to address the limitations of radiographic imaging and single-task learning models in adolescent idiopathic scoliosis assessment by developing a noninvasive, radiation-free diagnostic framework.

Methods: A multi-task deep learning model was trained using structured back surface data acquired via fringe projection three-dimensional imaging. The model was designed to simultaneously predict the Cobb angle, curve type (thoracic, lumbar, mixed, none), and curve direction (left, right, none) by learning shared morphological features.

Transformation of Polysulfide Catholyte Chemistry through Lithium-Arene Complexes for Superior Solubility and Cyclability in Li-S Batteries.

The development of high-performance lithium-sulfur batteries (LSBs) has been focused on overcoming the limitations associated with traditional polysulfide catholyte synthesis. We report an innovative catholyte synthesis method using lithium-arene complexes, offering significant advancements in terms of solubility, stability, and scalability. By leveraging the interaction of metallic lithium with biphenyl (BP) and sulfur, we developed a Li+BP+S catholyte formulation that outperforms conventional LiS+S systems.

Intermittent fasting reprograms the brain proteome to prevent synaptic degeneration and cognitive impairment in vascular dementia.

Vascular dementia (VaD), driven by chronic cerebral hypoperfusion (CCH), leads to synaptic degeneration and cognitive decline, yet mechanisms linking vascular dysfunction to synaptic loss remain unclear. Intermittent fasting (IF) has emerged as a potential intervention, but its effects on synaptic integrity in VaD are unknown. This study aims to investigate the effects of IF against synaptic degeneration and cognitive impairment induced by CCH.

The Calcium Pump ATP2B1/PMCA1 Regulates CNS Vascular Development by Facilitating Norrin- and WNT7A/B-induced Frizzled4 signaling.

Frizzled4 (FZD4) is a receptor for Norrin and WNT7A/B ligands, is expressed in endothelial cells (ECs), is required for blood-CNS-barrier function as well as CNS angiogenesis, and transduces β-catenin-dependent signaling. Despite its fundamental importance in neurovascular biology, including as drug target, the molecular mechanisms governing FZD4 regulation remain poorly understood. Here, we employed proximity biotinylation to identify proteins that regulate FZD4.

Influence of organic waste amendments on uptake of per and polyfluoroalkyl substances from soil to crops: Insights from long-term field experiments.

The use of organic waste products (OWPs) as soil amendments raises concerns due to the potential uptake and accumulation of several environmental contaminants, such as per- and polyfluoroalkyl substances (PFAS) in plants. We developed an analytical procedure suitable for screening 75 anionic, zwitterionic, and cationic PFAS in plant tissues (limits of detection: 0.01-0.