Perceptions and Experiences of HIV Nurses on Peer Support for People Living With HIV in the Netherlands: A Qualitative Study.

BackgroundPeer support is an important intervention to achieve increased quality of life for people with HIV. We set out to understand the perceptions and experiences of HIV nurses with peer support in the Netherlands.MethodsWe conducted 21 semi-structured interviews which were analysed using thematic analysis.

Co-occurrence of severe fatigue and insomnia: implications for the outcome of cognitive behavioural therapies.

Background: Cognitive behavioural therapy for fatigue (CBT-F) and insomnia (CBT-I) are effective therapies. Little is known on their effectiveness when severe fatigue and insomnia co-occur.

Aims: This observational study investigated whether the co-occurrence of fatigue and insomnia influences the outcomes of CBT-F and CBT-I.

The efficacy of personalization within psychological treatments compared to no or less personalization: A meta-analysis and systematic review.

Objective: This meta-analysis and systematic review assessed whether personalization within psychological treatments for mental health problems or persistent somatic symptoms improves treatment outcomes, compared to non- or less personalized treatments.

Method: APA PsycInfo, Cochrane Library, MEDLINE, and EMBASE were searched up to January 14, 2024, for randomized controlled trials comparing within-treatment personalization against no or less personalization. Risk of bias was assessed with the Cochrane tool.

Preferences for long-acting treatment among people with HIV: a discrete choice experiment.

Introduction: Long-acting regimens (LAR) are emerging as a promising strategy to enhance treatment satisfaction and improve quality of life of people with HIV. A comprehensive understanding of treatment preferences is essential to effectively address the needs and expectations of people with HIV.

Design: A discrete choice experiment (DCE) was conducted to identify preferences for LAR among people with HIV.

Stigma-related disclosure concerns and negative self-image have not improved over a decade in older people with HIV.

Objective: Stigma impedes the HIV care continuum and contributes to problematic mental health outcomes, non-adherence and reduced quality of life. We prospectively analysed changes in HIV stigma measures over 10-years among older people with HIV (PWH).

Design: PWH participating in the AGEhIV Cohort Study completed the full Berger HIV Stigma Scale (HSS) between 2012-2014 (T0) and two of the HSS subscales - i.

Mode of administration matters: Willingness of people with HIV to switch to future long-acting treatments, and health care professionals' intention to discuss these options.

Introduction: Understanding preferences for long-acting regimens (LAR) of people with HIV and health care professionals (HCPs) is important to optimize and personalize care. We identified preferences for current and future LAR among people with HIV and investigated HCPs' willingness to discuss these options.

Methods: This study was conducted during routine clinic visits at Amsterdam UMC between September 2023 and March 2024.

Treatment Preferences in Patients With Insomnia and Medical Comorbidity: Associated Factors and Impact on Treatment-Outcome.

Insomnia is common in patients with medical comorbidity. First-line treatment for insomnia is cognitive behavioural therapy for insomnia (CBT-I). However, some patients with medical comorbidities prefer pharmacological treatment.

Low dose amitriptyline versus cognitive behavioral therapy for insomnia in patients with medical comorbidity: results of a randomized controlled multicenter non inferiority trial.

Study Objectives: In a randomized controlled non-inferiority trial, we aimed to determine whether low dose Amitriptyline (AM), which is often used off-label, is a safe and effective alternative to cognitive behavioral therapy for insomnia (CBT-I) in the treatment of insomnia among patients with insomnia and medical comorbidity.

Methods: A total of 187 participants with insomnia and medical comorbidity were randomly allocated to either: 1) 12 weeks of AM, 10-20 mg (n = 93), or 2) 12 weeks of group CBT-I, 7 sessions (n = 94). Assessments took place at baseline, 6 and 12 weeks after start of treatment.

The expected impact of a cure for HIV among people with HIV and key populations.

Background: This study explored the expected impact of two hypothetical HIV cure scenarios on quality of life, sexual satisfaction, and stigma among people with HIV and key populations (i.e., partners and communities of people with HIV and men who have sex with men without HIV) in the Netherlands.

Long-term cognitive functioning following COVID-19: Negligible neuropsychological changes over time.

Objective cognitive impairment has been shown in a minority of hospitalized COVID-19 patients, and longitudinal studies with a relatively long follow-up duration are scarce. We sought to investigate the presence and long-term change of objective cognitive functioning. Forty-six initially hospitalized (18 ± 19 days) COVID-19 survivors (male/female: 30/16; age: 61 ± 11) underwent extensive neuropsychological assessment (including performance validity) approximately 1 (T1) and 2.

High Prevalence of Posttraumatic Stress Disorder Symptoms Found in Well-Treated People with HIV after the Introduction of Patient-Reported Outcome Measures.

People with HIV (PWH) are at greater risk of experiencing mental health problems, such as depression and post-traumatic stress disorder (PTSD). The purpose of our study was to determine the prevalence of posttraumatic stress disorder PTSD in PWH. PWH in care Amsterdam University Medical center (Amsterdam UMC) with access to the electronic patient portal were offered patient-reported outcome measures (PROMs) between May 2022 and May 2023, including the PC-PTSD-5 screen for PTSD as part of routine clinical care.

Patients' Experienced Usability and Satisfaction With Digital Health Solutions in a Home Setting: Instrument Validation Study.

Background: The field of digital health solutions (DHS) has grown tremendously over the past years. DHS include tools for self-management, which support individuals to take charge of their own health. The usability of DHS, as experienced by patients, is pivotal to adoption.

Long-term sequelae of SARS-CoV-2 two years following infection: exploring the interplay of biological, psychological, and social factors.

Background: Severe fatigue and cognitive complaints are frequently reported after SARS-CoV-2 infection and may be accompanied by depressive symptoms and/or limitations in physical functioning. The long-term sequelae of COVID-19 may be influenced by biomedical, psychological, and social factors, the interplay of which is largely understudied over time. We aimed to investigate how the interplay of these factors contribute to the persistence of symptoms after COVID-19.

Reasons for fear of cancer recurrence after endoscopic treatment of T1 esophageal adenocarcinoma. A semi-structured interview study.

Prior research has shown that patients with early Barrett's neoplasia treated endoscopically report at least the same level of fear for cancer recurrence as patients treated surgically for a more advanced disease stage. The aim of this qualitative study was to gain insight into the reasons why endoscopically treated patients fear or not fear cancer recurrence. Patients treated endoscopically for T1 esophageal adenocarcinoma participated in a semi-structured interview.

Neuropsychological functioning after COVID-19: Minor differences between individuals with and without persistent complaints after SARS-CoV-2 infection.

It is unclear how self-reported severe fatigue and difficulty concentrating after SARS-CoV-2 infection relate to objective neuropsychological functioning. The study aimed to compare neuropsychological functioning between individuals with and without these persistent subjective complaints. : Individuals with and without persistent severe fatigue (Checklist Individual Strength (CIS) fatigue ≥ 35) and difficulty concentrating (CIS concentration ≥ 18) at least 3 months after SARS-CoV-2 infection were included.

Inflammatory profiles are associated with long COVID up to 6 months after COVID-19 onset: A prospective cohort study of individuals with mild to critical COVID-19.

Background: After initial COVID-19, immune dysregulation may persist and drive post-acute sequelae of COVID-19 (PASC). We described longitudinal trajectories of cytokines in adults up to 6 months following SARS-CoV-2 infection and explored early predictors of PASC.

Methods: RECoVERED is a prospective cohort of individuals with laboratory-confirmed SARS-CoV-2 infection between May 2020 and June 2021 in Amsterdam, the Netherlands.

Quality of life improvement from thoracoscopic atrial fibrillation ablation in women versus men: a prospective cohort study.

Objectives: Thoracoscopic ablation has proven to be an effective and safe rhythm control strategy, especially for persistent atrial fibrillation. However, its impact on quality of life (QoL) and potential gender differences remains unclear.

Methods: This prospective, single-centre observational study included consecutive patients with symptomatic atrial fibrillation undergoing thoracoscopic ablation.

Postoperative quality of life and pain after upper hemisternotomy and conventional median sternotomy for aortic valve replacement: results of a randomized clinical trial.

Objectives: Surgical aortic valve replacement through conventional sternotomy yields excellent results. Minimally invasive techniques are deemed equally safe and serve as a viable and less traumatic alternative. However, it is unclear how both surgical techniques affect patient-reported outcomes.

Control of complement-induced inflammatory responses to SARS-CoV-2 infection by anti-SARS-CoV-2 antibodies.

Dysregulated immune responses contribute to the excessive and uncontrolled inflammation observed in severe COVID-19. However, how immunity to SARS-CoV-2 is induced and regulated remains unclear. Here, we uncover the role of the complement system in the induction of innate and adaptive immunity to SARS-CoV-2.

Implementation of 'IBD-Specific Cognitive Behavioural Therapy' for Patients with Inflammatory Bowel Diseases with Poor Mental Quality of Life, Anxiety and Depression.

This paper describes the implementation of inflammatory bowel disease (IBD)-specific cognitive behavioural therapy (CBT) for IBD patients with poor quality of life (QoL), anxiety and depression, in four hospitals in the Netherlands. Treatment outcomes were compared with those of a previously published randomized control trial (RCT) of 'IBD-specific CBT', following a benchmark strategy. Primary outcome was IBD-specific QoL (IBDQ) completed before and after CBT, secondary outcomes were anxiety and depressive symptoms (HADS, CES-D).

Insomnia and sleep characteristics in post COVID-19 fatigue: A cross-sectional case-controlled study.

Objective: Following COVID-19 many patients report persistent fatigue and insomnia. Given the overlapping features, insomnia can be underdiagnosed in post-COVID-19 fatigue patients. This study aimed to determine insomnia severity, prevalence of clinical insomnia and sleep characteristics of post-COVID-19 fatigue patients.

Optimising HIV care using information obtained from PROMs: protocol for an observational study.

Introduction: Successful antiviral therapy has transformed HIV infection into a chronic condition, where optimising quality of life (QoL) has become essential for successful lifelong treatment. Patient-reported outcome measures (PROMs) can signal potential physical and mental health problems related to QoL. This study aims to determine whether PROMs in routine clinical care improve quality of care as experienced by people with HIV (PWH).

Between delivering chronic care and answering patients' burdens: Understanding HIV specialist nurses' experiences in the age of treatment.

Aim(s): To understand the experiences of HIV nurses in the context of ambivalence between biomedical treatment advancements and the continuing burden for people living with HIV and negative representations of HIV.

Design: An interpretative phenomenological study was conducted using in-depth interviews.

Methods: Twenty-one interviews with nurses were conducted between November 2021 and March 2022.