Metabolite profiling and neuroprotective potential of Clitoria ternatea L. through in-vitro and in-vivo experimental models.

Introduction: Alzheimer's disease is a growing concern in the global population, affecting learning, memory and causes neurodegeneration. Clitoria ternatea L. (Fabaceae), is used traditionally to treat cognitive dysfunction by improving memory.

Antiviral efficacy of hexane extract of Hypericum gaitii Haines against Chikungunya and SARS-CoV-2 viruses: in vitro and in silico approaches.

Ethnopharmacological Relevance: Viral infections have become a public health concern globally. The limited efficacy of existing antivirals against emerging viruses encourages extensive research to find alternative strategies. In this scenario, various plant bioactive compounds have been reported to possess potential against a wide range of illnesses, including viral diseases.

Quantification of anthocyanins in Oryza sativa L. from Jammu and Kashmir, India by a validated high performance thin layer chromatography (HPTLC) method.

Anthocyanins are bioactive compounds with antioxidant, anti-obesity, and anti-inflammatory properties beneficial for human health. HPTLC is an effective technique that is ideal for analysing both qualitatively and quantitatively. One of the advantages of HPTLC over HPLC (High performance liquid chromatography) and LC-MS (Liquid chromatography mass spectrometry) is the capability to analyse crude samples consisting of various compounds along with the capacity to apply multiple samples and a range of standards on a single plate with enhanced accuracy and precision of quantification without constrains of time.

Immunomodulatory activity of bamboo biosilica from Dendrocalamus longispathus Kurz. - Metabolomics integrated network pharmacology approach.

Background: Bamboo has been used in traditional Asian medicine since ancient times. Silica is formed in the shoot internodes of various bamboo species. This bamboo-derived silica, referred to as bamboo biosilica or "banslochan" (in Sanskrit), possesses multiple health benefits.

Toxicological evaluation of Isosecotanapartholide from Artemisia vulgaris L.: oral acute and sub-acute toxicity in BALB/c mice.

Isosecotanapartholide (ISTP) isolated from Artemisia vulgaris, having fumigant property, was tested for acute and sub-acute toxicity in BALB/c mice. The male and female BALB/c mice were given ISTP orally for 7 days at doses of 200, 800 and 1600 mg/kg body weight (bw) for the acute toxicity assay. For sub-acute toxicity test, ISTP was given orally for 14 days at doses of 50 and 500 mg/kg bw.

Endotoxin (lipopolysaccharide)-induced inflammation in albino rat and macrophages (RAW 264.7): Piper mullesua leaf extract as promising therapeutic against inflammatory pathophysiology via SOCS1 activation and phospho-NF-κB/JAK1/STAT1 inhibition.

The present investigation has been attempted for scientifically validating the traditional uses of Piper mullesua against inflammatory pathophysiology using both in vivo (albino rats) and in vitro (macrophage cells, RAW 264.7) models of inflammation caused by an endotoxin (lipopolysaccharide, LPS). Oral gavaging with PMHAE, hydroalcoholic extract of Piper mullesua leaves, dose-responsively (50, 100, or 200 mg/kg BW, 14 days) restored any alteration in the concentration of serum inflammatory cytokines, IL-6, TNF-α, IL-4, and IL-10 and decreased prostaglandin (PGE2) and nitrite count in rats injected (i.

Metabolomic study of Polygonum posumbu Buch. Ham. Ex D. Don integrating with anti-diabetic potential - a mechanistic approach.

The present investigation aimed to evaluate the anti-diabetic effect of the well-known food plant Polygonum posumbu along with the mechanism of combining its in-vitro, in-vivo effects and UHPLC-QTOF-MS based phytochemical profiling linked with the network pharmacology. In-vitro anti-diabetic potential of the extract was determined by testing against α-amylase and α-glucosidase enzymes. The in-vivo anti-diabetic effect of the extract was investigated in STZ-induced diabetic mice.

Therapeutics of bitter plants from Northeast region of India and their pharmacological and phytochemical perspectives.

Natural resources have been used for food and medicine since the beginning of human civilization, and they have always been a low-cost, easily accessible source for individuals. Northeast region of India (NER) represents a significant portion of India's flora and fauna. Marginality, fragility, inaccessibility, ethnicity, and cultural diversity thrived in the region, resulting in the richest reservoir of genetic variation of bioresources.

A Validated Method for Identification and Quantification of Anthocyanins in Different Black Rice (Oryza sativa L.) Varieties Using High-Performance Thin-Layer Chromatography (HPTLC).

Introduction: Black rice (Oryza sativa L.) has gained prominence as a functional food because of its rich content of anthocyanins and polyphenols, offering potential health benefits. However, comprehensive research addressing the diverse anthocyanin compositions in black rice cultivars remains limited.

Capsaicin content in chillies ( L., s L., Jacq.) of Northeast India by high performance thin layer chromatography (HPTLC).

Capsaicin is the primary bioactive constituent in chillies, responsible for its incomparable pungent taste and many health advantages. In the current study, 32 samples of three different species of ( L., s L.

Metabolite Profiling and Integrated Network Pharmacology Based Mechanism of Benincasa hispida (Thunb.) Cogn. Fruit Against Non-insulin-Dependent Diabetes Mellitus.

Introduction: Benincasa hispida (Thunb.) Cogn. (Cucurbitaceae) is an essential food plant in India possessing antihyperglycemic and antihyperlipidemic activities.

Antidiabetic and Antioxidant Activities of Indian Bay Leaf (Cinnamomum tamala (Buch.-Ham.) T. Nees & Eberm.) Essential Oils Collected from Meghalaya.

The current work investigates the chemodiversity, in vitro antioxidant, α-amylase and α-glucosidase inhibitory potential of Cinnamomum tamala (CT) leaf essential oil (EO) collected from different localities of East Khasi Hills District of Meghalaya, India. Gas chromatography-mass spectrometry (GC-MS) analysis of all the extracted leaf essential oils facilitated the identification of several compounds in a variable range along with eugenol as the major component (74.79-95.

Rapid quality assessment and traceability of ginger powder from Northeast India and Indian market based on near infrared spectroscopic fingerprinting.

Introduction: Ginger (Zingiber officinale Rosc.) varies widely due to varying concentrations of phytochemicals and geographical origin. Rapid non-invasive quality and traceability assessment techniques ensure a sustainable value chain.

Chemo-profiling and exploring therapeutic potential of Momordica dioica Roxb. ex Willd. for managing metabolic related disorders: In-vitro studies, and docking based approach.

Ethnopharmacological Relevance: Momordica dioica Roxb. ex Willd. (M.

Bioeconomy and ethnopharmacology - Translational perspective and sustainability of the bioresources of northeast region of India.

Ethnopharmacological Relevance: The ecological environment of Northeast region of India (NER), with its high humidity, has resulted in greater speciation and genetic diversity of plant, animal, and microbial species. This region is not only rich in ethnic and cultural diversity, but it is also a major biodiversity hotspot. The sustainable use of these bioresources can contribute to the region's bioeconomic development.

Genomic insights from BRD3A isolated from Atingba, a traditional fermented rice-based beverage and analysis of its potential for probiotic and antimicrobial activity against Methicillin-resistant .

BRD3A was isolated from Atingba, a traditional fermented rice-based beverage of Manipur. Its genomic sequence has 13 contigs and its genome size is 3,320,817 bp with a guanine-cytosine (GC) ratio of 44.6%.

Exploration of anti-diabetic activity and metabolite profiling of Bruguiera cylindrica (l.) Bl.-in vivo anti-diabetic activity, exploration of molecular mechanism, and network pharmacological analysis.

Introduction: The Bruguiera cylindrica L. is a mangrove plant that is typically found in coastal areas of Asia, including India. It has been known for its medicinal properties, which have been utilized for generations.

Ethno-entomotherapeutic and metabolite profiling of Coridius chinensis (Dallas), a traditional edible insect species of North-East India.

Edible insects possess several health enhancing properties and play an important role in human nutrition. Coridius chinensis is an edible insect that is considered food and claimed as traditional medicine. In the present study, nutritional contents, chemical composition, antioxidant, and anti-inflammatory properties of C.

Bio-economic potential of ethno-entomophagy and its therapeutics in India.

Insects are the largest group of arthropods with the highest faunal diversity of over a million species. Apart from many other roles in the environment, the aspect of several insects being used for human consumption (entomophagy) and as traditional medicine (entomotherapy) by different communities of the world holds special significance for countering global food crisis. The enormous insect resources contribute a reasonable share in improving the livelihoods of many entomophagy practicing communities.

Phytochemically analysed extract of Ageratina adenophora (Sprengel) R.M.King & H. Rob. initiates caspase 3-dependant apoptosis in colorectal cancer cell: A synergistic approach with chemotherapeutic drugs.

Ethnopharmacological Relevance: Ageratina adenophora (Sprengel) R.M.King & H.

Hydroalcoholic root extracts of Houttuynia cordata (Thunb.) standardized by UPLC-Q-TOF-MS/MS promotes apoptosis in human hepatocarcinoma cell HepG2 via GSK-3β/β-catenin/PDL-1 axis.

Houttuynia cordata (Thunb.), an important medicinal plant of Northeast India, Korea, and China, is used to treat various ailments and for anticancer research. Knowing its traditional practices, we are interested in the mode-of-action of HCT on HepG2 to co-relate the traditional practice with modern drug therapeutics.

Investigation on Anti-diabetic Efficacy of a Cucurbitaceae Food Plant from the North-East Region of India: Exploring the Molecular Mechanism through Modulation of Oxidative Stress and Glycosylated Hemoglobin (HbA1c).

Background: The medicinal plants of the Cucurbitaceae family, such as Lour. fruits, have significant ethnobotanical value and are readily accessible in North East India.

Aims: We conducted a study on Lour.

Socio-economic sustainability with circular economy - An alternative approach.

As the global population and living standards rise, it pushes the demand for basic amenities like food, health, and energy resources. Additionally, manufacturing automation has led to mass production and consumption, triggering waste production. The existing linear economy approach has led to increasing waste production and resource depletion, posing significant environmental and public health threats.

Quality evaluation of different black rice varieties of northeastern region of India.

Introduction: Black rice (Oryza sativa L.), which is rich in polyphenols and flavonoids, is indigenous to Northeast India, specifically Manipur, and traditionally consumed for its protective effects on human health. Due to its economic value, it is crucial to evaluate the quality of different black rice varieties to authenticate their therapeutic and nutritional properties.

Corrigendum: Standardised Buch.-Ham. fruit extract inhibits human neutrophil elastase and attenuates elastase-induced lung injury in mice.

[This corrects the article DOI: 10.3389/fphar.2022.