Publications by authors named "Pronab Kumar Modak"
OMNIgene.SPUTUM for transporting sputum in ambient temperature for tuberculosis testing: Bangladesh experience.
J Clin Tuberc Other Mycobact Dis
August 2025
Background: Performance of OMNIgene.SPUTUM (OM-S) for transporting sputum was evaluated.
Methods: This exploratory study was conducted during January-December 2019 at four near and one distant healthcare-facilities of Dhaka.
Article Synopsis
- * Conducted in nine health facilities, the study analyzed sputum samples from 1,084 TB patients, revealing a 6.4% general rate of INH resistance, notably higher in patients previously treated for TB.
- * Findings show that Hr-TB prevalence (4.5%) is more than double that of multi-drug-resistant TB (1.9%), underscoring the need for improved diagnostic methods for timely treatment of INH-resistant cases in the country.
Targeted next-generation sequencing of from patient samples: lessons learned from high drug-resistant burden clinical settings in Bangladesh.
Emerg Microbes Infect
December 2024
Lack of appropriate early diagnostic tools for drug-resistant tuberculosis (DR-TB) and their incomplete drug susceptibility testing (DST) profiling is concerning for TB disease control. Existing methods, such as phenotypic DST (pDST), are time-consuming, while Xpert MTB/RIF (Xpert) and line probe assay (LPA) are limited to detecting resistance to few drugs. Targeted next-generation sequencing (tNGS) has been recently approved by WHO as an alternative approach for rapid and comprehensive DST.
View Article and Find Full Text PDF