Assessment of non-steroidal anti-inflammatory drugs use and its complications among pediatric patients at a private tertiary care hospital in Malaysia.

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed to pediatric patients, but inappropriate use can lead to adverse health outcomes. Therefore, a study was conducted to analyse the prescribing patterns and drug-related problems (DRPs) associated with NSAIDs among pediatric patients at a private tertiary care hospital in Malaysia.

Methods: This single-centre, ambidirectional cohort study was conducted at a private tertiary care hospital in Kuala Lumpur, Malaysia, from January 2024 to March 2025.

Smoking cessation behavior, nicotine addiction, and mental health among current smokers in Klang Valley, Malaysia- a cross-sectional questionnaire survey.

Background: Poor knowledge of smoking-related diseases is a major concern as smoking is associated with an increasing trend in smoking-related illnesses globally and in Malaysia. Our study aimed to investigate the knowledge of smoking tobacco, smoking behaviour, nicotine use, willingness to quit smoking, and level of stress, anxiety, and depression among current and former smokers in the Klang Valley of Malaysia.

Method: A cross-sectional study was conducted online from March 2023 to January 2024, using a structured, validated questionnaire.

Insights into the Diagnosis, Treatment, and Management of Prion Diseases.

The normal cellular prion protein (PrPC) can misfold into an infectious and pathogenic form (PrPSc) to produce prion diseases, also known as transmissible spongiform encephalopathies (TSEs), which are rare and deadly neurodegenerative conditions. The conversion of PrPC to PrPSc, which builds up as toxic aggregates in the central nervous system, is caused by sporadic, inherited, or acquired pathways. PrPSc-induced proteostasis failure, oxidative stress, neuronal toxicity, and progressive neurodegeneration are characteristics of pathogenesis.

Enhancing knowledge, attitude, and perceptions towards fall prevention among older adults: a pharmacist-led intervention in a primary healthcare clinic, Gemas, Malaysia.

Background: Falls and fall-related injuries are very common among older adults, and the risk of falls increases with the aging process. The lack of awareness of falls and fall-related injuries among older adults can contribute to an increasing risk of falls. Hence, a study was carried out to improve the knowledge, attitude, and perception of falls and fractures among older adults in a primary care setting in Gemas, a rural area of the Selangor state of Malaysia.

Relationship between Treatment Burden, Health Literacy, and Medication Adherence in Older Adults Coping with Multiple Chronic Conditions.

A prospective study was conducted to investigate the impact of treatment burden and health literacy on medication adherence among older adults with multiple chronic conditions (MCC) and to explore the potential moderating effects of demographic and clinical factors. Face-to-face structured interviews were conducted among older adults aged 60 and above using the Burden of Treatment Questionnaire (TBQ-15), Short Form Health Literacy Questionnaire (HLS-SF12), and Malaysia Medication Adherence Assessment Tool (MyMAAT). This study included 346 older adults aged 60 years and above with two or more chronic conditions (n = 346).

Development and novel therapeutics in hepatocellular carcinoma: a review.

This review summarizes the epidemiological trend, risk factors, prevention strategies such as vaccination, staging, current novel therapeutics, including the drugs under clinical trials, and future therapeutic trends for hepatocellular carcinoma (HCC). As HCC is the third most common cause of cancer-related death worldwide, its overall incidence remains alarmingly high in the developing world and is steadily rising across most of the developed and developing world. Over the past 15 years, the incidence of HCC has more than doubled and it increases with advancing age.