Publications by authors named "Prashanth Vijayaraghavan"
Article Synopsis
- Glioma is a rare but aggressive brain tumor, with familial glioma being a genetically influenced form that makes up about 5% of cases.
- Researchers conducted whole-genome sequencing on 203 individuals from 189 families with familial glioma, also validating findings in a separate group of 122 individuals.
- The study identified significant variants in seven genes, particularly affecting tumor cell proliferation, highlighting the importance of these genes in understanding familial glioma.
Short Tandem Repeats (STRs) have been found to play a role in a myriad of complex traits and genetic diseases. We examined the variability in the lengths of over 850,000 STR loci in 996 children with suspected genetic disorders and 1,178 parents across six separate ancestral groups: Africans, Europeans, East Asians, Admixed Americans, Non-admixed Americans, and Pacific Islanders. For each STR locus we compared allele length between and within each ancestry group.
View Article and Find Full Text PDFHemodialysis (HD) in neonates and infants poses unique challenges due to high risks of mortality attributable to obligatory small blood flow volumes. Although HD is often necessary in neonates, its effectiveness and feasibility are poorly understood. The aim of this review is to describe in detail the few studies reporting on HD in neonates and infants (<12 months old) and then dissertate more broadly on the subject with an emphasis on recent innovations with potential to overcome traditional barriers for effective HD in this population.
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