Publications by authors named "Pramathesh Kumar Dandsena"
Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis (TB), modulates host immune responses by regulating various cytokines. Precise regulation of these cytokines renders the host pathogen-free, whereas their dysregulation increases the susceptibility to infection.
View Article and Find Full Text PDFThe bacterial genus Streptomyces is known for the prolific production of secondary metabolites, which exhibit remarkable structural diversity and potent biological activities. Tuberculosis (TB) remains a formidable global health challenge exacerbated by the emergence of antimicrobial resistance (AMR), necessitating the discovery of novel therapeutic agents. The untapped potential of marine Streptomyces-derived secondary metabolites offers a promising avenue for screening anti-tubercular (anti-TB) compounds with unique chemical structures and potential bioactive properties.
View Article and Find Full Text PDFArticle Synopsis
- Mycobacterium tuberculosis is a leading cause of global mortality, and to combat it effectively, improvements in diagnostics, drug regimens, and vaccinations are essential.
- The study investigates Furamidine, a compound that may enhance autophagy—a defense mechanism against pathogens—by evaluating its effects on tuberculosis bacteria within human cells.
- Findings demonstrate that Furamidine reduces mycobacterial growth and induces autophagy by affecting intracellular calcium levels and activating specific proteins, suggesting it could be a promising approach to improve TB treatment.