Publications by authors named "Pradeep M Uppar"
While 2-Indolyl-1,3,4-oxadiazole derivatives are recognized for their antibacterial properties, their potential as anticancer agents remains underexplored. This study investigates the anti-breast cancer properties of a novel 2-Indolyl-1,3,4-oxadiazole compound, 5l, focusing on its ability to induce apoptosis, paraptosis, and autophagy, and targeting poly (ADP-ribose) polymerase (PARP1), a critical enzyme in DNA repair. A series of 1,3,4-oxadiazole derivatives (compounds 5a-5m) were synthesized using an optimized multi-step process, enhancing reaction efficiency and yield.
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- Increased expression of VEGFR-2 in cancer cells leads to enhanced survival, growth, and proliferation of these cells.
- The study evaluates indazolyl-acyl hydrazones as potential antioxidant and anticancer agents, with some compounds showing significant inhibitory activity against free radicals.
- Compounds 4f and 4j demonstrated effective cell viability results in MCF-7 breast cancer cells and favorable binding to VEGFR-2, indicating their potential as therapeutic agents.