Vitamin B levels in older adults with pre-frailty and frailty: the impact of MTHFR and TCN2 polymorphisms and their association with global DNA methylation and physical performance.

Background: Frailty syndrome poses significant challenges in older populations. Understanding the genetic and biochemical factors associated with frailty is essential for effective management strategies.

Methods: In this study, Thai older adults (≥ 60 years, n = 170) were assessed for physical parameters, levels of B vitamins, creatinine, and homocysteine.

Exploring DNA methylation age and the influence of physical performance, and hypertension on frailty in elderly women.

Epigenetic age provides a reliable biomarker for biological aging, reflecting the cumulative impact on health over time. Frailty is common among elderly individuals and is further compounded by hypertension, which increases the risk associated with aging. Therefore, we examined the relationship between epigenetic aging and frailty in a non-Western population and explored synergistic effects of frailty and hypertension on epigenetic age.

Regulatory roles of transposable elements on autism molecular neuropathology.

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by challenges in social communication and the presence of repetitive behaviors, typically diagnosed in early childhood. In this review, we searched PubMed and Google Scholar databases for relevant articles. ASD displays considerable heterogeneity in symptomatology and is more common in males, though shifting demographics indicate rising rates among minority populations.

Blood-based biomarkers derived from tumor-informed DNA methylation analysis for lung adenocarcinoma.

Objective: To identify robust markers of lung adenocarcinoma (LUAD) using DNA methylation profiles from blood samples informed by tissue lung adenocarcinoma.

Methods: This study analyzed 56 LUAD blood samples from patients attending clinic at Siriraj Hospital, Thailand and 51 samples from healthy participants, using 644 tumor and 59 normal tissue methylome datasets from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases for candidate gene identification. We performed comparative analysis to identify DNA methylation (DNAm) changes present in tumors that are also observable in blood, to be taken forward for validation.

Impact of combined exercise on blood DNA methylation and physical health in older women with obesity.

This study examined the effects of a 14-week combined exercise program on blood DNA methylation (DNAm) and its potential biological pathways in normal-weight, overweight, and obese older women. A total of 41 participants were assessed at baseline, 7 weeks, and 14 weeks into the training. Their whole-blood DNAm profiles were measured using the Infinitum MethylationEPIC BeadChip, alongside physical and biochemical health evaluations.

as the Causal Agent of Rust on Nectarine, Peach, and Japanese Plum in Highland Areas of Northern Thailand.

A severe outbreak of rust disease was observed on species, (peach), . var. (nectarine), and .