Discordance in Drug-Drug Interaction Alerts for Antidotes: Comparative Analysis of Electronic Databases and Interpretive Insights from AI Tools.

Background: Drug-drug interactions (DDIs) are a critical clinical concern, especially when administering multiple medications, including antidotes. Despite their lifesaving potential, antidotes may interact harmfully with other drugs. However, few studies have specifically investigated DDIs involving antidotes.

Major toxin composition of particulate matter from a coal-fired power plant and its proteomics-associated toxicological profiles in the lungs of balb/c mice.

This comprehensive study investigated fly ash particulate matter (PM) from Thailand's Mae Moh Coal-fired Power Plant, focusing on its major toxin composition and toxicological effects in mice. Chemical composition analysis using inductively coupled plasma-mass spectrometry identified iron (Fe) as the predominant heavy metal (101,067.31 ± 8246.

Assessing developmental and transcriptional effects of PM2.5 on zebrafish embryos.

Investigating fine particulate matter (PM2.5) toxicity is crucial for health risk assessment and pollution control. This study explores the developmental toxicity of two PM2.

Oral sub-chronic toxicity of fingerroot () rhizome extract formulation in Wistar rats.

Background: (fingerroot) rhizome extract contains two major bioactive components, panduratin A and pinostrobin. In our previous study, we found the anti-inflammatory effects of the fingerroot extract against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in golden Syrian hamsters. In the present study, we evaluated the sub-chronic toxicity of a fingerroot extract formulation over 90 consecutive days of oral administration.

Absolute oral bioavailability and possible metabolic pathway of panduratin A from extract in beagle dogs.

Context: Attempts are ongoing to develop medications to fight against the COVID-19 pandemic. Our previous study revealed the anti-SARS-CoV-2 activity of fingerroot [ (L.) Mansf.