Using Integrated Bioinformatics Analysis to Identify Saponin Formosanin C as a Ferroptosis Inducer in Colorectal Cancer with p53 and Oncogenic KRAS.

Ferroptosis, a form of cell death, is characterized by lipid peroxidation and is dependent on iron and reactive oxygen species (ROS). Here, through bioinformatics analysis, formosanin C was predicted to be a ferroptosis inducer in colorectal cancer (CRC) by suppressing antioxidation capacity. Indeed, formosanin C induced iron accumulation, lipid ROS formation, and ferroptosis in CRC.

Targeting GPX4 to Overcome Sorafenib Resistance of Human Hepatocellular Carcinoma by Inducing Ferroptosis.

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death. Sorafenib, a multikinase inhibitor, has been approved as a first-line systemic therapeutic for HCC patients based on the results of two large clinical trials, in which sorafenib significantly increased life expectancy of patients with Child Pugh A advanced stage of liver cancer, no matter which races they were or whether being infected with hepatitis B or C virus; however, its efficacy is compromised by the resistance of the tumor cells. By using integrative bioinformatics analysis, we identified ferroptosis as a candidate to modulate sorafenib-resistant HCC.

Hierarchically structured conductive hydrogels for electrically programmable drug delivery in a diabetic wound healing electronic patch.

Smart wound dressings that integrate advanced drug delivery strategies and electrical stimulation (ES) represent a revolutionary approach for improving diabetic wound healing. However, limited drug loading efficiency and delayed reactivity to electrical inputs make it difficult to practically implement ES-controlled drug release in hydrogel-coated electrodes. In order to address these limitations, we developed a hydrogel-based electronic wound dressing patch that enables highly programmable, ES-triggered drug delivery.