Publications by authors named "Pierfrancesco Alaimo Di Loro"

A useful parametric specification for the expected value of an epidemiological process is revived, and its statistical and empirical efficacy are explored. The Richards' curve is flexible enough to adapt to several growth phenomena, including recent epidemics and outbreaks. Here, two different estimation methods are described.

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Article Synopsis
  • Viral hepatitis is a global health issue, characterized by complex interactions between hepatitis viruses and human liver cells, affecting disease progression and severity.
  • The paper focuses on how different hepatitis viruses (B, C, D, and E) enter liver cells, replicate, evade the immune system, and cause liver damage, as well as the body's immune responses to these infections.
  • It emphasizes the importance of understanding individual factors influencing susceptibility to viral hepatitis and highlights new findings on chronic infection mechanisms, aiming to inform better treatment strategies.
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This work aims to show how prior knowledge about the structure of a heterogeneous animal population can be leveraged to improve the abundance estimation from capture-recapture survey data. We combine the Open Jolly-Seber model with finite mixtures and propose a parsimonious specification tailored to the residency patterns of the common bottlenose dolphin. We employ a Bayesian framework for our inference, discussing the appropriate choice of priors to mitigate label-switching and nonidentifiability issues, commonly associated with finite mixture models.

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The majority of Americans fail to achieve recommended levels of physical activity, which leads to numerous preventable health problems such as diabetes, hypertension, and heart diseases. This has generated substantial interest in monitoring human activity to gear interventions toward environmental features that may relate to higher physical activity. Wearable devices, such as wrist-worn sensors that monitor gross motor activity (actigraph units) continuously record the activity levels of a subject, producing massive amounts of high-resolution measurements.

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  • The study investigates chronotropic incompetence (CI) in heart failure with mildly reduced ejection fraction (HFmrEF) patients, focusing on its prevalence and effects on exercise capacity and cardiovascular outcomes.
  • Data from 864 stable HFmrEF outpatients showed significant variations in CI prevalence based on measurement methods, with a notable 9.7% rate of cardiovascular deaths over the study period.
  • The findings indicate that a blunted heart rate response during exercise is linked to lower functional capacity and increased cardiovascular death risk, suggesting the need for further research to determine if CI should be included in standard management for HFmrEF patients.
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Art experience is not solely the observation of artistic objects, but great relevance is also placed on the environment in which the art experience takes place, often in museums and galleries. Interestingly, in the last few years, the introduction of some forms of virtual reality (VR) in museum contexts has been increasing. This has solicited enormous research interest in investigating any eventual differences between looking at the same artifact either in a real context (e.

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  • This study examines exertional oscillatory breathing (EOV) as a potential indicator of prognosis in heart failure patients with reduced ejection fraction (HFrEF), focusing on how EOV changes during cardiopulmonary exercise tests (CPET).
  • Data from 1,866 HFrEF patients were analyzed, revealing that those with EOV experienced worse clinical outcomes, particularly over a 5-year period, compared to those without EOV.
  • Although EOV indicates a more severe progression of heart failure, the persistence of EOV did not prove to be a stronger predictor of cardiovascular outcomes than early cessation of EOV.
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Background: Short-term forecasts of infectious disease burden can contribute to situational awareness and aid capacity planning. Based on best practice in other fields and recent insights in infectious disease epidemiology, one can maximise the predictive performance of such forecasts if multiple models are combined into an ensemble. Here, we report on the performance of ensembles in predicting COVID-19 cases and deaths across Europe between 08 March 2021 and 07 March 2022.

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The amount and poor quality of available data and the need of appropriate modeling of the main epidemic indicators require specific skills. In this context, the statistician plays a key role in the process that leads to policy decisions, starting with monitoring changes and evaluating risks. The "what" and the "why" of these changes represent fundamental research questions to provide timely and effective tools to manage the evolution of the epidemic.

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We introduce an extended generalised logistic growth model for discrete outcomes, in which spatial and temporal dependence are dealt with the specification of a network structure within an Auto-Regressive approach. A major challenge concerns the specification of the network structure, crucial to consistently estimate the canonical parameters of the generalised logistic curve, e.g.

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A novel parametric regression model is proposed to fit incidence data typically collected during epidemics. The proposal is motivated by real-time monitoring and short-term forecasting of the main epidemiological indicators within the first outbreak of COVID-19 in Italy. Accurate short-term predictions, including the potential effect of exogenous or external variables are provided.

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Periodic assessments of population status and trends to detect natural influences and human effects on coastal dolphin are often limited by lack of baseline information. Here, we investigated for the first time the site-fidelity patterns and estimated the population size of bottlenose dolphins () at the Tiber River estuary (central Mediterranean, Tyrrhenian Sea, Rome, Italy) between 2017 and 2020. We used photo-identification data and site-fidelity metrics to study the tendency of dolphins to remain in, or return to, the study area, and capture-recapture models to estimate the population abundance.

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Objective: The present Italian multicenter study aimed at investigating whether the course of primary headache disorders in children and adolescents was changed during the lockdown necessary to contain the COVID-19 emergency in Italy.

Methods: During the lockdown, we submitted an online questionnaire to patients already diagnosed with primary headache disorders. Questions explored the course of headache, daily habits, psychological factors related to COVID-19, general mood and school stress.

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Background: Palmitoylethanolamide (PEA) is emerging as a new therapeutic approach in pain and inflammatory conditions, and it has been evaluated in studies on various painful diseases. The aim of this open-label study was to evaluate the efficacy of ultramicronized PEA (umPEA) in the prophylactic treatment of migraine.

Methods: The study included 70 patients with mean age of 10.

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Chronic headaches are not a rare condition in children and adolescents with negative effects on their quality of life. Our aims were to investigate the clinical features of chronic headache and usefulness of the International Classification of Headache Disorders 3rd edition (ICHD 3) criteria for the diagnosis in a cohort of pediatric patients. We retrospectively reviewed the charts of patients attending the Headache Center of Bambino Gesù Children and Insubria University Hospital during the 2010-2016 time interval.

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