Publications by authors named "Phoebe Moh"
An Evaluation-Focused Framework for Visualization Recommendation Algorithms.
IEEE Trans Vis Comput Graph
January 2022
Although we have seen a proliferation of algorithms for recommending visualizations, these algorithms are rarely compared with one another, making it difficult to ascertain which algorithm is best for a given visual analysis scenario. Though several formal frameworks have been proposed in response, we believe this issue persists because visualization recommendation algorithms are inadequately specified from an evaluation perspective. In this paper, we propose an evaluation-focused framework to contextualize and compare a broad range of visualization recommendation algorithms.
View Article and Find Full Text PDFA first-generation pediatric cancer dependency map.
Nat Genet
April 2021
Article Synopsis
- New therapeutic targets are being identified from CRISPR-based screens in adult cancers, raising questions about their applicability to pediatric cancers, which have fewer mutations.
- Researchers created a pioneering pediatric cancer dependency map that included 13 types of pediatric solid and brain tumors, analyzing 82 cell lines with CRISPR-Cas9 to uncover essential genes for survival.
- The study revealed that despite having fewer mutations, pediatric cancer cells exhibit similar complexity in genetic dependencies as adult cancer cells, suggesting that targeted treatments for childhood cancers will need to be developed separately from existing adult oncology drugs.
PRMT5 is an arginine methyltransferase that accounts for the vast majority of the symmetric methylation in cells. PRMT5 exerts its function when complexed with MEP50/WDR77. This activity is often elevated in cancer cells and correlates with poor prognosis, making PRMT5 a therapeutic target.
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