Pleural effusion due to dracunculus infection: a rare case in vietnam.

Guinea worm, scientific name is Dracunculus medinensis, is a rare parasite that causes disease in humans. People are infected with worms by drinking water containing cyclops carrying the larvae of Dracunculus medinensis. The cyclops dies after consumption, and the released larvae grow into adult worms by entering the host's digestive system.

Nitidine Isolated from the Bark of Zanthoxylum myriacanthum and its Effects on NTERA-2 Cancer Stem Cells.

Nitidine (NIT) was isolated from the bark of and assessed for anti-proliferative effects on NTERA-2 cancer stem cells using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay, spheroid assay, DNA and lysosome staining, flow cytometry, caspase assay, immunoblotting, and molecular docking studies. Moreover, nitidine suppresses stemness properties like tumorsphere forming, c-myc, Oct4, Nanog proteins of NTERA-2 cancer stem cells after 48-hour treatment. Nitidine selectively induced anti-survival activities by triggering the intrinsic apoptotic process through p53 signaling and lysosome-dependent cell death (LDCD).

Loranthus tienyenensis Li and Planchonella obovata (R. Br.) Pierre: Essential Oil Composition, Biological Activity, and Molecular Docking.

This study presents the first phytochemical analysis of the essential oils from the fresh leaves of Loranthus tienyenensis Li and Planchonella obovata (R. Br.) Pierre using gas chromatography-mass spectrometry.

Targeting SARS-CoV-2 RNA-dependent RNA polymerase with the coumarin derivative BPR2-D2: Evidence from cell-based and enzymatic studies.

The rapid mutation rate of SARS-CoV-2 highlights the urgent need for continuous drug development to enhance both efficacy and safety. BPR2-D2, an angular coumarin derivative, has previously shown notable anti-influenza activity and broad-spectrum inhibitory effects against RNA viruses. In this study, we found that BPR2-D2 exhibits potent antiviral activity against multiple SARS-CoV-2 variants, including several variants of concern, at nanomolar concentrations.

Tripeptides inhibit dual targets AChE and BACE-1: a computational study.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss, with amyloid-beta (Aβ) plaques and acetylcholine deficits being central pathological features. Inhibition of dual targets including acetylcholinesterase (AChE) and beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1) represents a promising strategy to address cholinergic deficits and amyloid pathology. In this study, we used computational approaches to evaluate 8000 tripeptides as potential dual inhibitors of AChE and BACE-1.

Chemical Composition and Pesticidal Activities Against Three Vector Mosquito Species of Zanthoxylum armatum DC. Essential Oils.

In this study, we investigated the extraction yield and chemical composition of essential oils from the fruit, leaf, and twig of Zanthoxylum armatum from Vietnam. The fruit essential oil (FEO) with high content, representing a chemotype, was evaluated for pesticidal activities against three mosquito species Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus, according to the WHO guidelines with modifications. The results showed that the major constituents of FEO were limonene (30.

Megastigmanes isolated from leaves and their immunomodulatory effect on IL-1β and IL-10 production in RAW264.7 macrophages.

With the aim of isolating immunomodulatory compounds from the -butanol extract of leaves, nine megastigmane compounds were identified. Among these, the structure of the new compound 1, namely, "boehmegaside A", was established using NMR and HR-ESI-MS, and its absolute configurations were established through ECD calculations and DP4+ analysis using DFT-NMR chemical shift calculations. Furthermore, eight of these compounds were discovered for the first time in the genus, marking this the first report on megastigmane compounds isolated from this genus.

Searching potential GSK-3β inhibitors from marine sources using atomistic simulations.

Glycogen synthase kinase-3 beta, GSK-3β, is one of the most common targets for cancer treatment. Inhibiting the biological activity of the enzyme can lead to the prevention of cancer development. Especially, estimating a new inhibitor for preventing GSK-3β by using natural compounds is of great interest.

HOO radical scavenging activity of curcumin I and III in physiological conditions: a theoretical investigation on the influence of acid-base equilibrium and tautomerism.

Curcumin possesses various effective medicinal properties, such as anti-cancer, anti-Alzheimer's, anti-inflammatory, and antioxidant effects, where its free radical scavenging activities play a crucial role in its therapeutic mechanisms. Although the antioxidant properties of curcumin and its derivatives have been previously studied, a systematic investigation of the thermodynamics and kinetics of the reaction with the hydroperoxide radical (HOO˙) - a standardized free radical - in different solvents is lacking. This study examined the HOO˙ radical scavenging activities of two curcumin derivatives, specifically curcumin I (Cur-I) and curcumin III (Cur-III), in water and pentyl ethanoate (PEA) solutions using Density Functional Theory (DFT) approaches.

Clinical characteristics and symptoms associated with infections among heterosexual men in Hanoi, Vietnam.

Background: (MG) is a critical pathogen of sexually transmitted infections (STIs) in men, associated with high antibiotic resistance. Understanding the clinical characteristics of MG infections can improve testing and treatment guidelines.

Aims: To investigate the clinical features and characteristics of asymptomatic, acute and chronic MG infections in heterosexual males.

Design, synthesis, anti-inflammatory evaluation, and molecular docking studies of novel quinazoline-4(3)-one-2-carbothioamide derivatives.

In this paper, a series of novel quinazoline-4(3)-one-2-carbothioamide derivatives (8a-p) were designed and synthesized the Wilgerodt-Kindler reaction between 2-methylquinazoline-4-one 10 and amines using S/DMSO as the oxidizing system. Their characteristics were confirmed by IR, NMR, HRMS spectra, and their melting point. These novel derivatives (8a-p) were evaluated for their anti-inflammatory activity by inhibiting NO production in lipopolysaccharide (LPS)-activated RAW 264.

Unprecedented large outbreak of malaria in Vietnam: Epidemiological and clinical perspectives.

, a causative agent of quartan malaria, is prevalent across tropical and subtropical regions, but global cases have been usually very rare and sporadic. However, a significant outbreak of quartan malaria caused by occurred in Khanh Vinh District, Khanh Hoa Province, Vietnam in 2023 and the outbreak persists. In this report, we present the epidemiological and clinical characteristics of this unprecedented outbreak of quartan malaria in Vietnam.

Searching for potential acetylcholinesterase inhibitors: a combined approach of multi-step similarity search, machine learning and molecular dynamics simulations.

Targeting acetylcholinesterase is one of the most important strategies for developing therapeutics against Alzheimer's disease. In this work, we have employed a new approach that combines machine learning models, a multi-step similarity search of the PubChem library and molecular dynamics simulations to investigate potential inhibitors for acetylcholinesterase. Our search strategy has been shown to significantly enrich the set of compounds with strong predicted binding affinity to acetylcholinesterase.

Essential Oils of The Leaves of Syzygium hemilamprum (F. Muell.) Craven & Biffin.: Chemical Analysis, Antimicrobial, Mosquito Larvicidal, Molecular Docking, and ADMET Studies.

The chemical composition of the essential oil and n-hexane extract from Syzygium hemilamprum leaves was first performed. Gas chromatography-mass spectrometry (GC-MS) analysis revealed that the essential oil was predominantly composed of monoterpene hydrocarbons (71.5 %) and oxygenated derivatives (20.

MedChemExpress compounds prevent neuraminidase N1 physics- and knowledge-based methods.

Influenza A viruses spread out worldwide, causing several global concerns. Hence, discovering neuraminidase inhibitors to prevent the influenza A virus is of great interest. In this work, a machine learning model was employed to evaluate the ligand-binding affinity of 10 000 compounds from the MedChemExpress (MCE) database for inhibiting neuraminidase.

Silver nanoparticles alter the dimerization of Aβ studied by REMD simulations.

The aggregation of amyloid beta (Aβ) peptides is associated with the development of Alzheimer's disease (AD). However, there has been a growing belief that the oligomerization of Aβ species in different environments has a neurotoxic effect on the patient's brain, causing damage. It is necessary to comprehend the compositions of Aβ oligomers in order to develop medications that may effectively inhibit these neurotoxic forms that affect the nervous system of AD patients.

ZIKV Inhibitors Based on Pyrazolo[3,4-]pyridazine-7-one Core: Rational Design, Evaluation, and Theoretical Studies.

The Zika virus (ZIKV) is believed to cause birth defects, and no anti-ZIKV drugs have been approved by medical organizations to date. Starting from antimicrobial lead compounds with a pyrazolo[3,4-]pyridazine-7-one scaffold, we synthesized 16 derivatives and screened their ability to interfere with ZIKV infection utilizing a cell-based phenotypic assay. Of these, five compounds showed significant inhibition of ZIKV with a selective index value greater than 4.

A new benzophenanthridine alkaloid from stem bark of and its biological activities.

A new benzophenanthridine alkaloid 6-butanoyldihydrochelerythrine and five known alkaloids 6-acetonyldihydronitidine , 6-acetonyldihydrochelerythrine , isocorydine , (O)-methyltembamide , N-(4-methoxyphenethyl)benzamide were isolated from the stem barks of . These structures were elucidated by 1D, 2D NMR spectroscopy and by mass spectrometry. This is the first time that compounds were identified from and the first time that compounds and were identified from the genus .

Perceived intravaginal ejaculation latency time: The diagnosis of premature ejaculation among Vietnamese men.

Introduction: Premature ejaculation (PE) is a prevalent sexual dysfunction in men that greatly affects their quality of life. In PE, the duration of sexual performance is considered an important aspect. However, a self-estimated value of intravaginal ejaculation latency time (perceived IELT, PIELT) as a criterion for diagnosis has not been specified.

Testosterone and aging male, a perspective from a developing country.

Purpose: Hypogonadism is associated with a wide range of physical and psychological symptoms that can affect the overall health of men. However, in a developing country, there are several imposing challenges in the diagnosis and treatment of hypogonadism, including a lack of awareness and understanding of the condition among healthcare providers and patients, limited resources and the high cost of treatment. This review aimed to examine the potential benefits and risks of testosterone replacement therapy (TRT) and provides a perspective of a developing country on the topic.

Upgrading nirmatrelvir to inhibit SARS-CoV-2 Mpro via DeepFrag and free energy calculations.

The first oral drug for the treatment of COVID-19, Paxlovid, has been authorized; however, nirmatrelvir, a major component of the drug, is reported to be associated with some side effects. Moreover, the appearance of many novel variants raises concerns about drug resistance, and designing new potent inhibitors to prevent viral replication is thus urgent. In this context, using a hybrid approach combining machine learning (ML) and free energy simulations, 6 compounds obtained by modifying nirmatrelvir were proposed to bind strongly to SARS-CoV-2 Mpro.

Component and Content of Lipid Classes and Phospholipid Molecular Species of Eggs and Body of the Vietnamese Sea Urchin .

Sea urchins () are among the most highly prized seafood products in Vietnam because of their nutritional value and medicinal properties. In this research, lipid classes and the phospholipid (PL) molecular species compositions from the body and eggs of collected in Hon Tam, Nha Trang, Khanh Hoa, Vietnam, were investigated. Hydrocarbon and wax (HW), triacylglycerol (TG), mono- and diacylglycerol (MDAG), free fatty acid (FFA), sterol (ST), polar lipid (PoL), and monoalkyl-diacylglycerol are the major lipid classes.

Plant Secondary Metabolites on Efflux-Mediated Antibiotic Resistant : Potential of Herbal-Derived Efflux Pump Inhibitors.

During the process of adapting to metal contamination, plants produce secondary metabolites that have the potential to modulate multidrug-resistant (MDR) phenotypes; this is achieved by inhibiting the activity of efflux pumps to reduce the minimum inhibitory concentrations (MICs) of antimicrobial substrates. Our study evaluated the effect of secondary metabolites of belowground parts of L. and two metal-tolerant plants from northern Vietnam, on six antibiotic-resistant strains possessing efflux pump resistance mechanisms that were isolated from soil and clinical samples.