Whole blood transfusion in pediatric trauma patients with traumatic brain injury may decrease the risk of early death.

Objective: There has been a resurgence in the use of whole blood for trauma resuscitation, however the outcomes for pediatric trauma patients with traumatic brain injury (TBI) resuscitated with whole blood are unknown. We hypothesized a lower risk of mortality and complications for pediatric trauma patients with TBI resuscitated with whole blood compared with those resuscitated exclusively with component blood therapy.

Methods: The 2020-2021 TQIP database was queried for pediatric trauma patients (≤ 17 years-old) with TBI requiring blood product resuscitation.

Assessing the Safety of Nonintensive Care Unit Admission for Select Grade III Blunt Splenic Trauma.

Introduction: Patients with grade III blunt splenic injuries (BSIs) may require splenectomy. Currently, there is practice variation for admission of these patients to an intensive care unit (ICU) or non-ICU floor. We hypothesized that select BSI patients may be admitted to non-ICU locations without increased complications, death, or need for splenectomy.

Predictors of ventilator-associated pneumonia in intubated pediatric trauma patients.

Purpose: Ventilator-associated pneumonia (VAP) is the most common complication among intubated pediatric trauma patients (PTPs) in pediatric intensive care units. Early identification of associated risk factors may help mitigate adverse outcomes linked to VAP, such as increased mortality and healthcare costs. This study aims to identify risk factors associated with VAP for intubated PTPs.

Early Experience Using Venous Sheath With Embolic Protection During Thrombectomy of Inferior Vena Cava and Complex Iliofemoral Deep Vein Thrombosis.

Percutaneous thrombectomy of the inferior vena cava (IVC) and complex iliocaval lesions may cause thromboembolism. The Inari Protrieve sheath is a device with a 33.5 mm funnel at the tip that can serve as embolic protection during thrombectomy procedures to mitigate the risk of pulmonary embolisms (PEs).

Main versus segmental hepatic artery angioembolization in patients with traumatic liver injuries: A Western Trauma Association multicenter study.

Introduction: Hepatic angioembolization is highly effective for hemorrhage control in hemodynamically stable patients with traumatic liver injuries and contrast extravasation. However, there is a paucity of data regarding the specific location of angioembolization within the hepatic arterial vasculature and its implications on patient outcomes.

Methods: A post-hoc analysis of a multicenter prospective observational study across 23 centers was performed.

Observation-first versus angioembolization-first approach in stable patients with blunt liver trauma: A WTA multicenter study.

Background: Prior studies evaluating observation versus angioembolization (AE) for blunt liver injuries (BLT) with contrast extravasation (CE) on computed tomography imaging have yielded inconsistent conclusions, primarily due to limitations in single-center and/or retrospective study design. Therefore, this multicenter study aims to compare an observation versus AE-first approach for BLT, hypothesizing decreased liver-related complications (LRCs) with observation.

Methods: We conducted a post hoc analysis of a multicenter, prospective observational study (2019-2021) across 23 centers.

Lack of Association Between the CCR5-delta32 Polymorphism and Neurodegenerative Disorders.

Objective: Recent studies have suggested that diminished Ccr5 functioning has an effect on synaptic plasticity and hippocampal memory in mouse models. CCR5-delta32, a 32-bp frameshift deletion in human CCR5 encoding a nonfunctional receptor, has been reported to have a protective effect against human immunodeficiency virus infection but its role as a modifier of neurodegenerative disease has been minimally explored. We investigated whether the CCR5-delta32 polymorphism could have an effect in the context of human neurodegenerative diseases.