Publications by authors named "Peng-Quan Chen"
Article Synopsis
- Type 2 diabetes mellitus (T2DM) is linked to cognitive issues and mood disorders, with melatonin (MLT) potentially influencing these neuropsychiatric functions.
- Researchers studied 126 T2DM patients, measuring MLT levels and correlating them with inflammation markers, cognitive executive functions, and depression tendencies.
- Findings showed that lower MLT levels in patients with higher blood glucose (HbA1c) correlated with greater cognitive and depressive symptoms, suggesting MLT could be a key factor for therapy and predicting these impairments in T2DM.
Differential toxic and antiepileptic features of Vigabatrin raceme and its enantiomers.
Brain Res
September 2024
Background: The study aimed to investigate the potential pharmacological and toxicological differences between Vigabatrin (VGB) and its enantiomers S-VGB and R-VGB. The researchers focused on the toxic effects and antiepileptic activity of these compounds in a rat model.
Methods: The epileptic rat model was established by intraperitoneal injection of kainic acid, and the antiepileptic activity of VGB, S-VGB, and VGB was observed, focusing on the improvements in seizure latency, seizure frequency and sensory, motor, learning and memory deficits in epileptic rats, as well as the hippocampal expression of key molecular associated with synaptic plasticity and the Wnt/β-catenin/GSK 3β signaling pathway.